Weather-Related Factors and Patient-Reported Outcomes (PROs) in Cancer Patients: Results from the ExPRO Study
Salm H, Eichler M, Bahr J, Andreou D, Schmidt C, Uhlig S and Pink D
Weather-Related Factors and Patient-Reported Outcomes (PROs) in Cancer Patients: Results from the ExPRO Study
Salm H, Eichler M, Bahr J, Andreou D, Schmidt C, Uhlig S and Pink D
The ExPRO (External factors influencing patient reported outcomes of patients with malignant diseases) study explored associations between QoL data and environmental factors on the day of questionnaire completion: mean temperature, sunshine hours, season, and lunar phase.
REM obstructive sleep apnea: prevalence and clinical associations in a high-altitude population
Severiche Bueno DF, Gonzalez AM, Rivera-Leon DP, Vargas Cuervo MT, Mateus-Palacios JM, Agudelo-Agudelo J, Casas DP, Enciso-B LF, Proaños NJ, Fernández-Bernal F, Dueñas Meza E, Gonzalez M and Bazurto Zapata MA
REM obstructive sleep apnea: prevalence and clinical associations in a high-altitude population
Severiche Bueno DF, Gonzalez AM, Rivera-Leon DP, Vargas Cuervo MT, Mateus-Palacios JM, Agudelo-Agudelo J, Casas DP, Enciso-B LF, Proaños NJ, Fernández-Bernal F, Dueñas Meza E, Gonzalez M and Bazurto Zapata MA
REM-associated OSA (REM OSA) has a prevalence of 17-74% of all OSA cases. At high altitude and in Latin America, there are no data on REM OSA and its relationship to daytime sleepiness and comorbidities. This study aimed to determine the prevalence of REM OSA and the differences in clinical and polysomnographic characteristics between OSA and REM OSA in a population living at 2640 m.
Progressive central cardiorespiratory rate downregulation and intensifying epilepsy lead to sudden unexpected death in epilepsy in mouse model of the most common human ATP1A3 mutation
Hunanyan AS, Verma A, Bidzimou MT, Biswas DD, Da Cruz E, Srour MK, Marek J, Hume C, Elmallah MK, Landstrom AP and Mikati MA
Progressive central cardiorespiratory rate downregulation and intensifying epilepsy lead to sudden unexpected death in epilepsy in mouse model of the most common human ATP1A3 mutation
Hunanyan AS, Verma A, Bidzimou MT, Biswas DD, Da Cruz E, Srour MK, Marek J, Hume C, Elmallah MK, Landstrom AP and Mikati MA
This study was undertaken to test the following hypotheses in the Atp1a3 mouse (which carries the most common human ATP1A3 (the major subunit of the neuronal Na/K-adenosine triphosphatase [ATPase]) mutation, D801N): sudden unexpected death in epilepsy (SUDEP) occurs during seizures and is due to terminal apneas in some and due to lethal cardiac arrhythmias in others; and Atp1a3 mice have central cardiorespiratory dysregulation and abnormal respiratory drive.
Incidence of adult tonsillectomy for hypertrophic indications in Southwest Finland
Sjöblom HM, Knubb JC, Kauko T, Pulkkinen J and Piitulainen JM
Incidence of adult tonsillectomy for hypertrophic indications in Southwest Finland
Sjöblom HM, Knubb JC, Kauko T, Pulkkinen J and Piitulainen JM
Large palatine tonsils cause a variety of symptoms including obstructive sleep apnea and snoring. In adults, the prevalence of tonsillar hypertrophy remains uncertain.
Effect of Probiotics on the Symptomatology of Autism Spectrum Disorder and/or Attention Deficit/Hyperactivity Disorder in Children and Adolescents: Pilot Study
Rojo-Marticella M, Arija V and Canals-Sans J
Effect of Probiotics on the Symptomatology of Autism Spectrum Disorder and/or Attention Deficit/Hyperactivity Disorder in Children and Adolescents: Pilot Study
Rojo-Marticella M, Arija V and Canals-Sans J
The aim of this study is to investigate the impact of using probiotics with strains related to dopamine and gamma-aminobutyric acid production on clinical features of autism spectrum disorder (ASD) and/or attention deficit/hyperactivity disorder (ADHD). This randomized, controlled trial involved 38 children with ADHD and 42 children with ASD, aged 5-16 years, who received probiotics (Lactiplantibacillus plantarum and Levilactobacillus brevis 109/cfu/daily) or placebo for 12 weeks. Parent-reported symptoms were assessed using Conners' 3rd-Ed and the Social Responsiveness Scale Test, 2nd-Ed (SRS-2), and children completed the Conners Continuous Performance Test, 3rd-Ed (CPT 3) or Conners Kiddie CPT, 2nd-Ed (K-CPT 2). Executive functions, quality of life and sleep patterns were also parent-assessed. Intention-to-treat analyses, controlling for sociodemographic and nutritional covariates, revealed no significant inter-group differences in parent-reported or neuropsychological data after the probiotic intervention. However, age-stratified analyses showed improved hyperactivity-impulsivity symptoms in younger children with ASD (Cohen's d = 1.245) and ADHD (Cohen's d = 0.692). Intra-group analyses supported these findings in the aforementioned age and intervention group for both diagnoses. An improvement in impulsivity for children with ASD was also observed in the intra-group analysis of the CPT commissions scores (probiotic: p = 0.001, Cohen's d = -1.216; placebo: p = 0.013, Cohen's d = -0.721). A better comfort score (quality of life) was shown in children with ASD (probiotic: p = 0.010, Cohen's d = 0.722; placebo: p = 0.099, Cohen's d = 0.456). The probiotics used, may improve hyperactivity-impulsivity in children with ASD or/and ADHD and quality of life in children with ASD. Further research is warranted to explore probiotics as an adjunctive therapeutic intervention for NDs.Trial registration: clinicaltrials.gov Identifier: NCT05167110.
Unveiling the Role of TBK1 as a Novel Biomarker in Obstructive Sleep Apnea Syndrome
Ko CY
Unveiling the Role of TBK1 as a Novel Biomarker in Obstructive Sleep Apnea Syndrome
Ko CY
Empowering the Sports Scientist with Artificial Intelligence in Training, Performance, and Health Management
Mateus N, Abade E, Coutinho D, Gómez MÁ, Peñas CL and Sampaio J
Empowering the Sports Scientist with Artificial Intelligence in Training, Performance, and Health Management
Mateus N, Abade E, Coutinho D, Gómez MÁ, Peñas CL and Sampaio J
Artificial Intelligence (AI) is transforming the field of sports science by providing unprecedented insights and tools that enhance training, performance, and health management. This work examines how AI is advancing the role of sports scientists, particularly in team sports environments, by improving training load management, sports performance, and player well-being. It explores key dimensions such as load optimization, injury prevention and return-to-play, sports performance, talent identification and scouting, off-training behavior, sleep quality, and menstrual cycle management. Practical examples illustrate how AI applications have significantly advanced each area and how they support and enhance the effectiveness of sports scientists. This manuscript also underscores the importance of ensuring that AI technologies are context-specific and communicated transparently. Additionally, it calls for academic institutions to update their curriculums with AI-focused education, preparing future sports professionals to fully harness its potential. Finally, the manuscript addresses future challenges, such as the unpredictable nature of team sports, emphasizing the need for interdisciplinary collaboration, including clear communication and mutual understanding between sports scientists and AI experts, and the critical balance between AI-driven insights and human expertise.
The Use of Principal Component Analysis for Reduction in Sleep Quality and Quantity Data in Female Professional Soccer
Barba E, Casamichana D, Figueiredo P, Nakamura FY and Castellano J
The Use of Principal Component Analysis for Reduction in Sleep Quality and Quantity Data in Female Professional Soccer
Barba E, Casamichana D, Figueiredo P, Nakamura FY and Castellano J
The main aim of the present study was to uncover multivariate relationships between sleep quantity and quality using principal component analysis (PCA) in professional female soccer players. A second aim was to examine the extent to which objective sleep quantity and quality variables can discriminate between perceived sleep. Ten objective sleep variables from the multisensory sleep-tracker were analyzed. PCA was conducted on the sleep variables, and meaningful principal components (PCs) were identified (eigenvalue > 2). Two sleep PCs were identified, representing the 'quantity of sleep' (quantity PC: eigenvalue = 4.1 and variance explained = 45.1%) and the 'quality of sleep' (quality PC: eigenvalue = 2.4 and variance explained = 24.1%). Cluster analysis grouped the players' sleep into three types: long and efficient, short and efficient, and long and inefficient; however, no association was found between the perceived sleep and the sleep clusters. In conclusion, a combination of both quantity and quality sleep metrics is recommended for sleep monitoring of professional female soccer players. Players should undergo a training process to improve self-assessment of sleep quality recorded from a subjective questionnaire, contrasting the perceived information with the sleep quality recorded objectively during a defined period in order to optimize the validity of their perceptions. The aim is to optimize the validity of their perceptions of sleep quality.
The Role of Rapid Maxillary Expansion in the Management of Obstructive Sleep Apnoea: Monitoring Respiratory Parameters-A Systematic Review and Meta-Analysis
Hariharan A, Muwaquet Rodriguez S and Hijazi Alsadi T
The Role of Rapid Maxillary Expansion in the Management of Obstructive Sleep Apnoea: Monitoring Respiratory Parameters-A Systematic Review and Meta-Analysis
Hariharan A, Muwaquet Rodriguez S and Hijazi Alsadi T
Obstructive sleep apnoea (OSA) is a sleep-related breathing condition that involves the presence of episodic disruptions to the sleeping pattern due to partial or complete airway obstruction. There are a range of treatment options that exist to alleviate the symptoms of this condition including CPAP, mandibular advancement, and maxillary expansion techniques. This systematic review and meta-analysis of published articles aims to determine if rapid maxillary expansion ("RME") is an effective treatment option in the management of OSA, using quantitative parameters of AHI and SpO. An exhaustive review of the literature was conducted on EBSCO, PubMed, and Scopus databases. The PICO question for the systematic review was "Can rapid maxillary expansion be used as a viable treatment option using comparative AHI and SpO parameters in the management of obstructive sleep apnoea?" A meta-analysis was also performed and the software used to carry out the meta-analysis was R 4.3.2 (R Core Team (2013)). From the initial search, 62 articles were found and a further 4 articles were obtained from manual findings. Nine articles were included in the final systematic review and meta-analysis. Eight of the studies concluded that RME was successful to varying degrees in the management of OSA across both outcome variables assessed. The meta-analysis indicated that RME is an effective treatment option in the management of adult and paediatric OSA with the improvement of both parameters. The paediatric OSA sample with specific pre-treatment anatomical presentation (clear maxillary deficiency, narrow hard palate with crossbite) showed a noted resolution of OSA following RME at a pre-pubertal age, indicating that RME can be employed as a genuine treatment option for paediatric OSA as suggested by theory. The systematic review and meta-analysis provided sufficient significant data in favour of the alternative hypothesis to indicate that RME is an effective treatment option in the management of obstructive sleep apnoea, in terms of the AHI reduction and SpO increase.
Adapting and validating the satisfaction, alertness, timing, efficiency, and duration-breast cancer (SATED-BC) scale for measuring sleep health in Spanish women treated for breast cancer
González-Santos Á, Lozano-Lozano M, Cantarero-Villanueva I, Postigo-Martín P, Martín-Martín L, Gil-Gutiérrez R, Muelas-Lobato R and Lopez-Garzon M
Adapting and validating the satisfaction, alertness, timing, efficiency, and duration-breast cancer (SATED-BC) scale for measuring sleep health in Spanish women treated for breast cancer
González-Santos Á, Lozano-Lozano M, Cantarero-Villanueva I, Postigo-Martín P, Martín-Martín L, Gil-Gutiérrez R, Muelas-Lobato R and Lopez-Garzon M
After breast cancer (BC), women may face other severe symptoms such as sleep problems. The use of simple, fast, and reliable scales is necessary in the clinic to improve patient benefits, and sleep is an important aspect to be addressed.
