Behavioral deficits after traumatic brain injury: Neuroprotective effect of Diosmin
Boldaji VN, Mirshekar MA, Arabmoazzen S and Shahrivar FF
Behavioral deficits after traumatic brain injury: Neuroprotective effect of Diosmin
Boldaji VN, Mirshekar MA, Arabmoazzen S and Shahrivar FF
Following traumatic brain injury (TBI), the progression of brain tissue injuries and subsequent psychiatric complications considerably affect the quality of life in humans. Diosmin (DM) is a flavonoid and has been demonstrated to improve cognitive deficit and amplify brain electrical activity in the rat model of traumatic brain injury. We aimed to explore the potential protective effects of DM on single-unit neuronal firing, as well as on motor function and behaviors related to depression and anxiety associated with TBI. Forty-eight Wistar rats were randomly divided into sham-operated, TBI, and TBI + DM (100 mg/kg/day; P.O.) Groups. Depression and anxiety-like behaviors and motor function were evaluated through standard behavioral tests and Rotarod apparatus at scheduled points in time. We also measured the neuronal firing rate in the striatum. The results indicated that DM pretreatment significantly improved TBI-induced depression and anxiety-like behaviors (P < 0.01), and motor coordination (P < 0.05). The striatum neuronal firing rate in the TBI + DM Group was significantly higher than the TBI group (216 Vs 49.38 Hz, P < 0.001). The findings suggest that pretreatment with DM may offer protective benefits against TBI-associated behavioral deficits.
Actigraphy-based sleep disruption and diurnal biomarkers of autonomic function in paroxysmal atrial fibrillation
Khazaie S, Wang L, Kaffashi F, Chung MK, Heinzinger CM, Van Wagoner DR, Loparo KA, Walia HK and Mehra R
Actigraphy-based sleep disruption and diurnal biomarkers of autonomic function in paroxysmal atrial fibrillation
Khazaie S, Wang L, Kaffashi F, Chung MK, Heinzinger CM, Van Wagoner DR, Loparo KA, Walia HK and Mehra R
Sleep architectural disruption is associated with atrial fibrillation (AF); however, associated autonomic influences remain unclear and it is unknown if this detriment persists during wakefulness. We hypothesize sleep disruption and autonomic dysfunction have diurnal patterning in patients with paroxysmal AF.
Prevalence, risk factors, and impacts of sleep disturbances in patients with primary brain tumors: a systematic review
Emamzadeh N, Abbasi F, Delfan N, Etemadi MH and Iranmehr A
Prevalence, risk factors, and impacts of sleep disturbances in patients with primary brain tumors: a systematic review
Emamzadeh N, Abbasi F, Delfan N, Etemadi MH and Iranmehr A
Sleep disturbances are common in patients with primary brain tumors (PBT), significantly affecting their health-related quality of life (QoL), emotional well-being, cognitive function, and clinical outcomes. These disturbances not only impact the patients themselves but also place a burden on their families and caregivers. Despite growing recognition of these problems, a comprehensive understanding of their prevalence, severity, and risk factors remains limited. This systematic review aimed to update the evidence on sleep disturbances in PBT patients, focusing on prevalence, risk factors, and management strategies. Following PRISMA 2020 guidelines, we searched PubMed, EMBASE, Scopus, PsycINFO, and CINAHL for studies published from September 2015 to June 2024. Eligible studies assessed sleep disturbances in adult PBT patients using validated methods. Studies with mixed-cancer samples, pediatric patients, or lacking validated sleep assessments were excluded. A total of 11 studies were included, revealing high rates of sleep disturbances, ranging from 9.2% to over 60%, varying by tumor type and treatment stage. Key risk factors included older age, female gender, certain tumor types (e.g., pituitary), perioperative sleep quality, and psychological distress. Sleep disturbances were linked to worse clinical outcomes, including higher mortality and burden. Addressing sleep disturbances through routine assessment and targeted interventions is essential for improving outcomes in this population.
Psychosomatic and medical experiences of menopause in Chinese women: a social media study
Xu Y, Ye S, Shi L and Zhang Z
Psychosomatic and medical experiences of menopause in Chinese women: a social media study
Xu Y, Ye S, Shi L and Zhang Z
Menopause has a significant effect on a woman's quality of life, which leads to physical illnesses and mental stresses. Social media listening (SML) studies reveal the experiences of users, sources of information on disease experiences and health dynamics in populations. The aim of this study was to assess the overview of portraits, complaints, symptom distribution and treatment methods of menopausal women through SML.
Evaluation of temporomandibular disorder self-management apps in Australia: a systematic review to inform clinical use
Lim A, Merner B, Iyer S and McCullough M
Evaluation of temporomandibular disorder self-management apps in Australia: a systematic review to inform clinical use
Lim A, Merner B, Iyer S and McCullough M
This study aimed to systematically evaluate apps with temporomandibular disorder (TMD) self-management content available in Australia for quality, clinical safety, self-management support functions, and contributors to app development.
Effects of jazz dance and concurrent training on physical variables in postmenopausal women
Fausto DY, Martins JBB, da Rocha ARA, Gil PR, Freitas CR, Pelegrini A and Guimarães ACA
Effects of jazz dance and concurrent training on physical variables in postmenopausal women
Fausto DY, Martins JBB, da Rocha ARA, Gil PR, Freitas CR, Pelegrini A and Guimarães ACA
This study aimed to analyze the effects of jazz dance or concurrent training on the cardiorespiratory fitness (CRF), muscle strength and sleep quality of postmenopausal women.
Vetiver and Orange Blossom Aid in Lowering Blood Pressure and Heart Rate and Improving Sleep Quality
Chang KM, Whu SW, Shen TS and Lai YJ
Vetiver and Orange Blossom Aid in Lowering Blood Pressure and Heart Rate and Improving Sleep Quality
Chang KM, Whu SW, Shen TS and Lai YJ
Aromatherapy has emerged as a prominent therapeutic modality, particularly for individuals grappling with insomnia and stress. This study delves into the sleep patterns of a general population and evaluates the impact of 3 distinct essential oils over a 4 to 6-week period. The study rigorously assesses changes in sleep quality and various cardiovascular parameters before and after the utilization of these essential oils. A total of 67 participants completed the Pittsburgh Sleep Quality Index (PSQI) questionnaire and expressed their willingness to partake in the experiment through an online platform. Subsequently, the participants underwent comprehensive measurements of cardiovascular and autonomic nervous system parameters. Following random assignment into 1 of 3 groups, the subjects diligently used the prescribed essential oils for the specified duration. A posttest was conducted to meticulously document the changes in cardiovascular and autonomic nervous system parameters, as well as the PSQI scale. The 3 essential oils employed were lavender, vetiver, and orange blossom, with 21, 18, and 17 participants, respectively. The experimental findings revealed a noteworthy reduction in PSQI scores after 4 to 6 weeks of using vetiver and orange blossom essential oils. The scores decreased from 7.92 (3.55) and 8.32 (3.71) to 6.08 (3.30, P = .007) and 6.47 (2.20, P = .042), respectively. This reduction was even more pronounced among subjects with initial PSQI scores of 5 or higher. Furthermore, the utilization of vetiver and orange blossom essential oils demonstrated a significant reduction in systolic blood pressure (SYS) over the 4 to 6-week period. Vetiver SYS levels decreased from 108.39 (5.67) to 105.33 (5.93) (P = .0016), and orange blossom SYS levels decreased from 110.53 (9.49) to 108.18 (9.49) (P = .0414). In addition, the heart rate of the vetiver group also exhibited a significant decrease from 78.33 (12.06) to 76.00 (12.06) (P = .0342). Thus, the results strongly suggest that vetiver and orange blossom essential oils contribute to the reduction of blood pressure, heart rate, and the enhancement of sleep quality, particularly in individuals experiencing sleep disturbances. These findings align with previous research on the soothing effects of essential oils and their potential in promoting both cardiovascular and sleep-related well-being.
Grounding as a complementary intervention for Alzheimer's disease: Mechanisms, evidence, and potential therapeutic applications
Kshirsagar S, Deshmukh H, Reddy AP, Reddy AP and Reddy PH
Grounding as a complementary intervention for Alzheimer's disease: Mechanisms, evidence, and potential therapeutic applications
Kshirsagar S, Deshmukh H, Reddy AP, Reddy AP and Reddy PH
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, neuroinflammation, oxidative stress, and mitochondrial dysfunction. Despite extensive research efforts, effective curative treatments remain elusive, emphasizing the need for innovative therapeutic strategies. Grounding, or earthing, involves direct physical contact with the Earth's surface to facilitate the absorption of negatively charged electrons into the body. This practice has gained attention for its potential to reduce inflammation, oxidative stress, and cortisol dysregulation, which are significant contributors to AD pathology. This review examines the biological mechanisms by which grounding may influence AD, including its antioxidative effects that mitigate oxidative stress and its anti-inflammatory properties that reduce neuroinflammation. Grounding may also improve sleep quality and stress management, factors known to exacerbate AD progression. Evidence from preclinical and clinical studies highlights its potential to protect neuronal health by targeting oxidative and inflammatory pathways. Additionally, the safety, feasibility, and cost-effectiveness of grounding are discussed, making it a practical complementary approach to existing AD therapies. While the preliminary evidence is promising, the review emphasizes the need for robust clinical trials to validate grounding's efficacy specifically in AD populations. By integrating grounding into standard care protocols, it may be possible to enhance the overall therapeutic outcomes and improve the quality of life for individuals with AD. Grounding represents a novel, non-pharmacological intervention that could complement existing treatments by addressing both the physiological and psychological aspects of this complex disease.
Long-term mortality and extrahepatic outcomes in 1,096 children with MASLD: A retrospective cohort study
Schwimmer JB, Thai NQN, Noon SL, Ugalde-Nicalo P, Anderson SR, Chun LF, David RS, Goyal NP, Newton KP, Hansen EG, Lin B, Shapiro WL, Wang A, Yu EL and Behling CA
Long-term mortality and extrahepatic outcomes in 1,096 children with MASLD: A retrospective cohort study
Schwimmer JB, Thai NQN, Noon SL, Ugalde-Nicalo P, Anderson SR, Chun LF, David RS, Goyal NP, Newton KP, Hansen EG, Lin B, Shapiro WL, Wang A, Yu EL and Behling CA
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease in children, but its long-term outcomes are poorly understood. This study aimed to quantify mortality rates, identify causes of death, and evaluate the incidence of cirrhosis and extrahepatic outcomes in children with pediatric-onset MASLD.
Understanding the impact of developmental coordination disorder on Belgian children and families: A national survey study
De Roubaix A, Warlop G, Van Dyck D, Van Crombrugge D, Van den Abbeele S, Licari M, Van Waelvelde H and Bar-On L
Understanding the impact of developmental coordination disorder on Belgian children and families: A national survey study
De Roubaix A, Warlop G, Van Dyck D, Van Crombrugge D, Van den Abbeele S, Licari M, Van Waelvelde H and Bar-On L
Developmental Coordination Disorder (DCD) is an under-recognized and often trivialized neurodevelopmental condition impacting five to six percent of children. This study aimed to map the impact of DCD on children and their families in Belgium.
