Assessment of Positional Obstructive Sleep Apnea in Children Undergoing Adenotonsillectomy for Obstructive Sleep Apnea
Ulualp SO, Johnson RF and Mitchell RB
Assessment of Positional Obstructive Sleep Apnea in Children Undergoing Adenotonsillectomy for Obstructive Sleep Apnea
Ulualp SO, Johnson RF and Mitchell RB
To determine the prevalence of positional obstructive sleep apnea (pOSA) in children undergoing adenotonsillectomy (AT) for OSA and to assess whether pOSA improves following AT.
Health Related Quality of Life in Adult Patients With Primary Glomerular Diseases
Grewal A, Bansal B, Subbiah A, Bhowmik D, Agarwal SK and Bagchi S
Health Related Quality of Life in Adult Patients With Primary Glomerular Diseases
Grewal A, Bansal B, Subbiah A, Bhowmik D, Agarwal SK and Bagchi S
There is a growing need to understand how glomerular diseases impact patients' ability to lead a healthy and productive life. We examined the Health-Related Quality of Life (HRQoL) in patients with primary glomerular diseases in India.
Prevalence of Metabolic Syndrome Among Adults Aged 50 and Above and Associated Factors: A Cross-Sectional Study From Ardakan Cohort Study on Aging (ACSA)
Hooshmand E, Akbarzade I, Delbari D, Niroomand M, Ghavidel F and Saatchi M
Prevalence of Metabolic Syndrome Among Adults Aged 50 and Above and Associated Factors: A Cross-Sectional Study From Ardakan Cohort Study on Aging (ACSA)
Hooshmand E, Akbarzade I, Delbari D, Niroomand M, Ghavidel F and Saatchi M
Metabolic syndrome (MetS) is one of the most important late-life diseases. This study was conducted to estimate the prevalence of MetS in the elderly population (over 50 years old) of Ardakan, Iran.
Use of Digital Health in Pediatric Asthma
Baker JA and Berlinski A
Use of Digital Health in Pediatric Asthma
Baker JA and Berlinski A
Asthma is a heterogeneous disease characterized by variable, reversible airway obstruction and hyper-responsive airways. In the United States, it is estimated nearly 25 million adults and children have asthma with over 4 million being children. Despite national and global asthma management guidelines, 44% of children report poor asthma control, resulting in higher health care utilization, greater number of missed work/school days, and poorer quality of life, all contributing to the United States' economic burden of more than $80 billion annually. The landscape of health care is transforming rapidly as technology advancements accelerate integration of digital health technology into patient care and management. Digital health technology uses computing platforms, connectivity, software, artificial intelligence, machine learning, and sensors to manage illnesses and health risks and promote wellness with a strong emphasis around personalized health care. This includes wearable devices, mobile health, telehealth, health information technology, remote monitoring, and telemedicine. A literature search on electronic monitoring for pediatric asthma was done that also included wearable devices, smart inhaler, digihaler, smart spacer, smart nebulizer, adherence monitoring, home spirometry, and symptom monitoring. The aim of this article is to review literature on how digital health technology can impact asthma care by identifying and educating about environmental triggers, prompting earlier recognition of asthma symptoms, and improving medication adherence and inhaler device technique.
Systematic review of longitudinal studies on daily health behavior and activity of daily living among older adults
Wang LY, Hu ZY, Chen HX, Zhu H, Zhou CF, Zhang RX, Tang ML and Hu XY
Systematic review of longitudinal studies on daily health behavior and activity of daily living among older adults
Wang LY, Hu ZY, Chen HX, Zhu H, Zhou CF, Zhang RX, Tang ML and Hu XY
Health behavior, as an intervention led by nursing staff, plays a pivotal role in enhancing the health of older adults. However, existing evidence has predominantly focused on isolated aspects (e.g., smoking, alcohol consumption, diet, or exercise), with most studies being cross-sectional, thereby limiting the ability to establish causal relationships between these factors and Activities of Daily Living (ADLs). A comprehensive synthesis of longitudinal studies is required to elucidate the impact of daily health behaviors on ADLs in older adults.
Evaluation of The Impact of Hypocretin Receptor 1 rs2271933 Polymorphism on Sleep Components in Chronic Migraine Patients with Poor Sleep Quality: A Subgroup Analysis
Genç H, Özçelik EU, Barlas İÖ, Öksüz N and Özge A
Evaluation of The Impact of Hypocretin Receptor 1 rs2271933 Polymorphism on Sleep Components in Chronic Migraine Patients with Poor Sleep Quality: A Subgroup Analysis
Genç H, Özçelik EU, Barlas İÖ, Öksüz N and Özge A
Long-reported dual comorbidity between migraine and sleep disorders suggests that some gene variations may play a role in this relationship. Our previous study found an association between poor sleep quality and the G allele of the hypocretin receptor 1 (HCRTR1) rs2271933 gene in patients with chronic migraine (CM). This study aimed to examine the relationship of this gene with some sleep parameters.
Neurological sequelae of long COVID: a comprehensive review of diagnostic imaging, underlying mechanisms, and potential therapeutics
Talkington GM, Kolluru P, Gressett TE, Ismael S, Meenakshi U, Acquarone M, Solch-Ottaiano RJ, White A, Ouvrier B, Paré K, Parker N, Watters A, Siddeeque N, Sullivan B, Ganguli N, Calero-Hernandez V, Hall G, Longo M and Bix GJ
Neurological sequelae of long COVID: a comprehensive review of diagnostic imaging, underlying mechanisms, and potential therapeutics
Talkington GM, Kolluru P, Gressett TE, Ismael S, Meenakshi U, Acquarone M, Solch-Ottaiano RJ, White A, Ouvrier B, Paré K, Parker N, Watters A, Siddeeque N, Sullivan B, Ganguli N, Calero-Hernandez V, Hall G, Longo M and Bix GJ
One lingering effect of the COVID-19 pandemic created by SARS-CoV-2 is the emergence of Long COVID (LC), characterized by enduring neurological sequelae affecting a significant portion of survivors. This review provides a thorough analysis of these neurological disruptions with respect to cognitive dysfunction, which broadly manifest as chronic insomnia, fatigue, mood dysregulation, and cognitive impairments with respect to cognitive dysfunction. Furthermore, we characterize how diagnostic tools such as PET, MRI, EEG, and ultrasonography provide critical insight into subtle neurological anomalies that may mechanistically explain the Long COVID disease phenotype. In this review, we explore the mechanistic hypotheses of these neurological changes, which describe CNS invasion, neuroinflammation, blood-brain barrier disruption, and gut-brain axis dysregulation, along with the novel vascular disruption hypothesis that highlights endothelial dysfunction and hypoperfusion as a core underlying mechanism. We lastly evaluate the clinical treatment landscape, scrutinizing the efficacy of various therapeutic strategies ranging from antivirals to anti-inflammatory agents in mitigating the multifaceted symptoms of LC.
Clinical efficacy and potential mechanisms of acupuncture for Parkinson's disease: the role of GABAergic signaling
Lu W, Zhang T, Li M, Zhang J, Liu N, Yang L and Huang G
Clinical efficacy and potential mechanisms of acupuncture for Parkinson's disease: the role of GABAergic signaling
Lu W, Zhang T, Li M, Zhang J, Liu N, Yang L and Huang G
Parkinson's disease (PD), a common neurodegenerative disease, seriously impacts the quality of life of patients. In recent years, research has revealed that the GABAergic signaling pathway plays an important role in the occurrence and development of PD. GABA is an important inhibitory neurotransmitter in the central nervous system (CNS), synthesized through the alpha decarboxylation reaction of glutamate (Glu) under the action of glutamic acid decarboxylase (GAD) in GABAergic neurons. It works by binding to specific receptors (GABA /GABA ). In PD patients, the activity of GABAergic neurons in the basal ganglia (BG) changes, leading to an imbalance between direct and indirect pathways and causing motor symptoms. Meanwhile, the GABAergic signaling pathway is closely related to non-motor symptoms such as anxiety, depression, and sleep disorders. At present, the treatment methods for PD mainly include drug therapy, surgical treatment, and rehabilitation therapy. Acupuncture, as a complementary and alternative therapy, has shown promising efficacy in the clinical treatment of PD. This review comprehensively and thoroughly explores the therapeutic effect of acupuncture on PD and its mechanism of action with GABAergic signaling. By systematically summarizing relevant research results, it was found that acupuncture may exert a complex mechanism of therapeutic effect by regulating the GABAergic signaling pathway. Further clarification of these mechanisms of action will be beneficial for promoting the application and development of acupuncture in the treatment of PD and is expected to provide new targets and strategies.
Investigating the Safety of Fampridine in Patients with Different Stages of Multiple Sclerosis
Vaheb S, Farzan M, Afshari-Safavi A, Ebrahimi N, Shaygannejad V and Mirmosayyeb O
Investigating the Safety of Fampridine in Patients with Different Stages of Multiple Sclerosis
Vaheb S, Farzan M, Afshari-Safavi A, Ebrahimi N, Shaygannejad V and Mirmosayyeb O
Fampridine is the only drug approved by the US Food and Drug Administration (FDA) for people with multiple sclerosis (MS) to improve their movement and has exhibited a clinically significant improvement in gait function in a subset of MS patients with Expanded Disability Status Scale (ESDSS) from 4 to 7. Nevertheless, this drug has been reported to possess some adverse effects (AEs) like seizure because of its pharmacological features. The aim of this study was to evaluate the incidence rate of post-medication side effects (SEs) of fampridine in MS patients.
Impact of circuit configuration on the mechanical performance of CPAP therapy devices: an experimental study
De Luca M, Formaggio A, Terzini M, Borrelli S, Putame G, Moretto F, Esposito T, Vaschetto R, Morbiducci U, Olivieri C and Audenino AL
Impact of circuit configuration on the mechanical performance of CPAP therapy devices: an experimental study
De Luca M, Formaggio A, Terzini M, Borrelli S, Putame G, Moretto F, Esposito T, Vaschetto R, Morbiducci U, Olivieri C and Audenino AL
CPAP therapy treats various respiratory disorders. The overall performance of therapy delivery can be affected by the adopted circuit configuration. Recently, parallel to the canonical open configuration (OC), closed configurations (CC) have been proposed with potential advantages in terms of oxygen consumption, noise, airway dryness and contamination. However, the mechanical performance of CPAP devices in CC has been marginally investigated. The aim of this study is to clarify whether CPAP therapy delivered in CC configuration retains mechanical performances equivalent to that achieved in the canonical OC stipulated by the manufacturers.
