Music Combined with Cognitive Behavioral Therapy Enhanced Functional Integration within the Frontal-Parietal-Temporal Brain Network in Patients with Chronic Subjective Tinnitus
Luo Y, Gao M, Xiao Y and Yang H
Music Combined with Cognitive Behavioral Therapy Enhanced Functional Integration within the Frontal-Parietal-Temporal Brain Network in Patients with Chronic Subjective Tinnitus
Luo Y, Gao M, Xiao Y and Yang H
This study was aimed at investigating the effectiveness of music combined with cognitive behavioral therapy (music-CBT) and its underlying therapeutic mechanisms in treating chronic subjective tinnitus.
Shedding Light on REM Sleep Behavior Disorder in Progressive Supranuclear Palsy: Window Into Neurodegeneration or Diagnostic Challenge?
Baldelli L and Calandra-Buonaura G
Shedding Light on REM Sleep Behavior Disorder in Progressive Supranuclear Palsy: Window Into Neurodegeneration or Diagnostic Challenge?
Baldelli L and Calandra-Buonaura G
Self-Reported REM Sleep Behavior Disorder in Patients With Progressive Supranuclear Palsy: Clinical and F-Florzolotau PET Imaging Findings
Li XY, Tang G, Lu J, Zhao Y, Lin H, Zhang Q, Chan K, Liang X, Wang J, Shen B, Tang Y, Zhao J, Sun YM, Wu J, Yen TC, Wang J, Zuo C, Liu FT and
Self-Reported REM Sleep Behavior Disorder in Patients With Progressive Supranuclear Palsy: Clinical and F-Florzolotau PET Imaging Findings
Li XY, Tang G, Lu J, Zhao Y, Lin H, Zhang Q, Chan K, Liang X, Wang J, Shen B, Tang Y, Zhao J, Sun YM, Wu J, Yen TC, Wang J, Zuo C, Liu FT and
Rapid eye movement sleep behavior disorder (RBD) is increasingly recognized in patients with tauopathies, but its significance and underpinnings remain unclear. To address this gap, we investigated the prevalence of self-reported RBD in patients with progressive supranuclear palsy (PSP) and explored its clinical and imaging correlates using F-florzolotau PET imaging.
Effect of isotretinoin treatment on sleep quality in acne vulgaris patients
Celik MS, Celik C and Cepik N
Effect of isotretinoin treatment on sleep quality in acne vulgaris patients
Celik MS, Celik C and Cepik N
Isotretinoin is a systemic treatment agent used in patients with severe acne vulgaris. It has been reported to have side effects associated with depression, sleep apnea, and hypersomnia. There are some studies in the literature suggesting that isotretinoin may cause sleep disturbances. The aim of this study was to investigate whether sleep quality is affected in acne vulgaris patients receiving isotretinoin treatment. Fifty patients with acne vulgaris who were receiving isotretinoin treatment and who were referred to the dermatology polyclinic were included in the study. Two Pittsburgh Sleep Quality Index (PSQI) questionnaires, consisting of 7 components and 19 items, were administered to the patients, one during the treatment period and one before the treatment period. Scores ranged from 0 to 21, with scores of 5 and above indicating poor sleep quality. Before isotretinoin treatment, the average PSQI score of male patients was 11.5 ± 4.95, while after treatment it was 18.0 ± 6.69. In female patients, the average PSQI score before treatment was 9.50 ± 4.81, During treatment, it was observed as 14.0 ± 6.28. An increase in scores was observed in both sexes after isotretinoin. The change before and after treatment was considered significant (P < 0.001). In our study, we observed a negative effect of isotretinoin on sleep quality. Some experimental studies have shown that retinoic acids can affect the pathways in the brain that regulate sleep, but further research is needed in this area.
Pons metabolite alterations in narcolepsy type 1
Mitolo M, Pizza F, Manners DN, Guidi L, Venneri A, Morandi L, Tonon C, Plazzi G and Lodi R
Pons metabolite alterations in narcolepsy type 1
Mitolo M, Pizza F, Manners DN, Guidi L, Venneri A, Morandi L, Tonon C, Plazzi G and Lodi R
Narcolepsy type 1 (NT1) is a rare central sleep disorder characterized by a selective loss of hypocretin/orexin (hcrt)-producing neurons in the postero-lateral hypothalamus that project to widespread areas of the brain and brainstem. The aim of this study was to explore in a group of NT1 patients the metabolic alterations in the pons and their associations with disease features.
Efficacy and outcomes of long-term non-invasive ventilation in children with Robin sequence
Faily V, Castro-Codesal M and MacLean JE
Efficacy and outcomes of long-term non-invasive ventilation in children with Robin sequence
Faily V, Castro-Codesal M and MacLean JE
To describe the clinical characteristics and outcomes of children with Robin sequence (RS) using non-invasive ventilation (NIV), including continuous and bilevel positive airway pressure, and to compare these parameters to other children using this technology.
Childhood Lifestyle Behaviors and Mental Health Symptoms in Adolescence
Haapala EA, Leppänen MH, Kosola S, Appelqvist-Schmidlechner K, Kraav SL, Jussila JJ, Tolmunen T, Lubans DR, Eloranta AM, Schwab U and Lakka TA
Childhood Lifestyle Behaviors and Mental Health Symptoms in Adolescence
Haapala EA, Leppänen MH, Kosola S, Appelqvist-Schmidlechner K, Kraav SL, Jussila JJ, Tolmunen T, Lubans DR, Eloranta AM, Schwab U and Lakka TA
Mental health problems often arise during adolescence and early adulthood, affecting up to 25% to 30% of young people. Enhancing the ability to identify children and adolescents at increased risk of mental health problems and uncover factors that promote mental health from childhood to adolescence is important.
K-Complex morphological alterations in insomnia disorder and their relationship with sleep state misperception
Gorgoni M, Fasiello E, Leonori V, Galbiati A, Scarpelli S, Alfonsi V, Annarumma L, Casoni F, Castronovo V, Ferini-Strambi L and De Gennaro L
K-Complex morphological alterations in insomnia disorder and their relationship with sleep state misperception
Gorgoni M, Fasiello E, Leonori V, Galbiati A, Scarpelli S, Alfonsi V, Annarumma L, Casoni F, Castronovo V, Ferini-Strambi L and De Gennaro L
Insomnia disorder (ID) is characterized by electroencephalographic indexes of hyperarousal, often associated with the underestimation of sleep duration (i.e., sleep state misperception). Albeit NREM sleep K-complexes (KCs) are involved in sleep protection and arousal, only a few studies investigated their alterations in ID with heterogenous findings, and results about their possible relationship with sleep state misperception are missing. The study aims to assess KCs in ID and their relationship with sleep state misperception, also considering their correlation with sleep architecture (i.e., the large-scale organization of sleep). Nineteen ID patients (12 F; age: 42.4±12.1 y) and 18 healthy controls (HC; 10 F; age: 41.6±11.9 y) underwent a night of home polysomnography and completed sleep diaries upon awakening. KC density, amplitude and area under the curve were assessed in midline frontal, central, and parietal derivations. Sleep state misperception was investigated by considering polysomnographic and subjective total sleep time (TST). We found reduced anterior KC morphology (i.e., amplitude and area under the curve) in ID patients compared to HCs, which was associated with TST underestimation. KC morphology was negatively associated with N3 latency, sleep fragmentation and arousal indexes, and positively related with N3 percentage and sleep efficiency. Our findings suggest an impaired sleep protection mechanism expressed by altered KCs morphology in ID involved in sleep state misperception. The observed correlations support the view of KC as forerunner of Slow Wave Sleep and protector of sleep continuity. A better understanding of sleep-protecting mechanisms alteration as a predisposing and/or maintaining factor of ID is needed.
Altitude-induced central sleep apnea does not affect mean sleep oxygen saturation in young healthy males
Heiniger G, Raemy F, Solelhac G, Imler T, Waeber A, Lambercy K, Bradley B, Lecciso G, Degache F and Heinzer RC
Altitude-induced central sleep apnea does not affect mean sleep oxygen saturation in young healthy males
Heiniger G, Raemy F, Solelhac G, Imler T, Waeber A, Lambercy K, Bradley B, Lecciso G, Degache F and Heinzer RC
At high-altitude, periodic breathing (PB) can occur during sleep in healthy individuals. PB is characterized by a cyclical ventilatory pattern that alternates between central sleep apnea and brief episodes of hyperventilation. The aim of this study was to evaluate the effect of periodic breathing on sleep SO. 36 healthy males subjects (median-age:26[24-28]years old, median BMI:22.7[21.1-23.8]Kg/m) underwent a polysomnography at a simulated altitude of 3,500 meters(FiO:13%). Correlations were sought between the Apnea-Hypopnea Index(AHI), Oxygen Desaturation Index(ODI), percentage of total sleep time spent in PB, and mean SO throughout the entire sleep period by calculating the Spearman's rank correlation test. We identified 20 participants who had experienced at least 3 minutes of PB adjacent to at least 3 minutes of regular breathing(RB). We compared the mean SO between the two respiratory patterns using Wilcoxon signed-rank test. At simulated-altitude, the subjects spent a median-IQR of 43.9[12.5-79.1]% of sleep in PB and the median-AHI was 77.3[31.4-127.5]/h. Median awake and asleep SO were 75.4[24-28]% and 68.5[66.4-72.5]% respectively. We found no within subject difference in SO between RB and PB periods (median-IQR RB vs PB: 67.2%{63.8-74.8%} vs 67.5%{64.5-73.9%},p=0.43). No significant correlation was found between the mean sleep SO and AHI(n=36,rs=-0.19,p=0.26), ODI(n=36,rs=-0.23,p=0.18) or PB(n=36,rs=-0.07,p=0.67). Awake SO was correlated with mean SO during sleep(n=36,rs=0.55;p=0.001). PB per se does not have a detrimental effect on mean SO in young healthy males. Correlation between awake and sleep SO, suggests that sleep SO at high-altitude is primarily determined by baseline oxygen saturation rather than the respiratory pattern developed during sleep.
Evaluating elexacaftor/tezacaftor/ivacaftor (ETI; Trikafta™) for treatment of patients with non-cystic fibrosis bronchiectasis (NCFBE): A clinical study protocol
Swenson CE, Hunt WR, Manfredi C, Beltran DJ, Hong JS, Davis BR, Suzuki S, Barillá C, Rab A, Chico C, Dangerfield J, Streby A, Barton E, Cox EM, Stecenko AA, Westbrook A, Kapolka R and Sorscher EJ
Evaluating elexacaftor/tezacaftor/ivacaftor (ETI; Trikafta™) for treatment of patients with non-cystic fibrosis bronchiectasis (NCFBE): A clinical study protocol
Swenson CE, Hunt WR, Manfredi C, Beltran DJ, Hong JS, Davis BR, Suzuki S, Barillá C, Rab A, Chico C, Dangerfield J, Streby A, Barton E, Cox EM, Stecenko AA, Westbrook A, Kapolka R and Sorscher EJ
Non-cystic fibrosis bronchiectasis (NCFBE) is a disease that exhibits dilatation of airways, airflow obstruction, persistent cough, excessive sputum production, and refractory respiratory infections. NCFBE exhibits clinical and pathological manifestations similar to key features of cystic fibrosis (CF) lung disease. In CF, pathogenesis results from dysfunction of the cystic fibrosis transmembrane conductance regulator (CFTR), and diagnosis is made by demonstrating elevated sweat chloride concentrations (typically ≥60 mEq/L), two CFTR mutations known to be causal, multi-organ tissue injury, or combination(s) of these findings.
