English English Spanish Spanish
Latest Physician News2019-02-15T12:10:02+00:00

Latest in Sleep Medicine News

Epidemiology of Obstructive Sleep Apnea: a Population-based Perspective

Several population-based studies across various geographical regions and ethnic groups have established a high prevalence of OSA. This epidemic of OSA is closely related to the obesity epidemic—an important public health related condition facing adults globally. In the United States in 2004, the estimated prevalence of adult obesity, classified as a body mass index (BMI) over 30 kg/m2, was more than 30% and the prevalence of extreme obesity (BMI > 40 kg/m2) was 2.8% in men and 6.7% in women [1]. Associated health care expenditures in obese individuals is 36% higher than normal weight persons, and it has been estimated that up to 7% of the annual health care expenditures is related to obesity [2,3]. Obesity is a well-recognized risk factor for a variety of medical conditions such as OSA, type 2 diabetes, cardiovascular diseases, hyperlipidemia, metabolic syndrome, and nonalcoholic fatty liver disease.

Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2727690/

The Food and Drug Administration has approved pitolisant (Wakix) for excessive daytime sleepiness among patients with narcolepsy, according to a release from the drug’s developer.

The Food and Drug Administration has approved pitolisant (Wakix) for excessive daytime sleepiness among patients with narcolepsy, according to a release from the drug’s developer. Approval of this once-daily, selective histamine 3–receptor antagonist/inverse agonist was based on a pair of multicenter, randomized, double-blind, placebo-controlled studies that included a total of 261 patients. Patients in both studies experienced statistically significant improvements in excessive daytime sleepiness according to Epworth Sleepiness Scale scores.

Rates of adverse advents at or greater than 5% and more than double that of placebo included insomnia (6%), nausea (6%), and anxiety (5%). Patients with severe liver disease should not use pitolisant. Pitolisant has not been evaluated in patients under 18 years of age, and patients who are pregnant or planning to become pregnant are encouraged to enroll in a pregnancy exposure registry.

Source: https://www.mdedge.com/chestphysician/article/206754/sleep-medicine/fda-approves-wakix-excessive-daytime-sleepiness

Association of estimated sleep duration and naps with mortality and cardiovascular events: a study of 116 632 people from 21 countries



To investigate the association of estimated total daily sleep duration and daytime nap duration with deaths and major cardiovascular events.

Methods and results

We estimated the durations of total daily sleep and daytime naps based on the amount of time in bed and self-reported napping time and examined the associations between them and the composite outcome of deaths and major cardiovascular events in 116 632 participants from seven regions. After a median follow-up of 7.8 years, we recorded 4381 deaths and 4365 major cardiovascular events. It showed both shorter (≤6 h/day) and longer (>8 h/day) estimated total sleep durations were associated with an increased risk of the composite outcome when adjusted for age and sex. After adjustment for demographic characteristics, lifestyle behaviours and health status, a J-shaped association was observed. Compared with sleeping 6–8 h/day, those who slept ≤6 h/day had a non-significant trend for increased risk of the composite outcome [hazard ratio (HR), 1.09; 95% confidence interval, 0.99–1.20]. As estimated sleep duration increased, we also noticed a significant trend for a greater risk of the composite outcome [HR of 1.05 (0.99–1.12), 1.17 (1.09–1.25), and 1.41 (1.30–1.53) for 8–9 h/day, 9–10 h/day, and >10 h/day, Ptrend < 0.0001, respectively]. The results were similar for each of all-cause mortality and major cardiovascular events. Daytime nap duration was associated with an increased risk of the composite events in those with over 6 h of nocturnal sleep duration, but not in shorter nocturnal sleepers (≤6 h).


Estimated total sleep duration of 6–8 h per day is associated with the lowest risk of deaths and major cardiovascular events. Daytime napping is associated with increased risks of major cardiovascular events and deaths in those with >6 h of nighttime sleep but not in those sleeping ≤6 h/night.

Chuangshi Wang, Shrikant I Bangdiwala, Sumathy Rangarajan, Scott A Lear,Khalid F AlHabib, Viswanathan Mohan, Koon Teo, Paul Poirier, Lap Ah TSE, Zhiguang Liu, Annika Rosengren, Rajesh Kumar, Patricio Lopez-Jaramillo, Khalid Yusoff, Nahed Monsef,Vijayakumar Krishnapillai, Noorhassim Ismail, Pamela Seron, Antonio L Dans,Lanthé Kruger, Karen Yeates, Lloyd Leach, Rita Yusuf, Andres Orlandini, Maria Wolyniec,Ahmad Bahonar, Indu Mohan, Rasha Khatib, Ahmet Temizhan, Wei Li,

Source: https://academic.oup.com/eurheartj/article-abstract/40/20/1620/5229545

Latest in Sleep Medicine Research

  1. Kendall, F, Silva, G, Almeida, J, Eusébio, E, Pinho, P, Oliveira, J et al.. Influence of Respiratory Muscle Training on Patients' Recovery after Lung Resection. Int J Sports Med. 2020; :. doi: 10.1055/a-1096-0913. PubMed PMID:32252100 .
  2. Olive, LS, Emerson, CA, Cooper, E, Rosenbrock, EM, Mikocka-Walus, AA. Fatigue, Physical Activity, and Mental Health in People Living With Inflammatory Bowel Disease, Fibromyalgia, and in Healthy Controls: A Comparative Cross-Sectional Survey. Gastroenterol Nurs. ;43 (2):172-185. doi: 10.1097/SGA.0000000000000415. PubMed PMID:32251219 .
  3. Bueno, CGR, Andrechuk, CRS, Ceolim, MF. Is Sleep Quality Impaired and Is There Increased Risk of Obstructive Sleep Apnea Syndrome in Patients With Compensated Liver Cirrhosis?. Gastroenterol Nurs. ;43 (2):126-134. doi: 10.1097/SGA.0000000000000411. PubMed PMID:32251214 .
  4. Elías, MN, Munro, CL, Liang, Z, Padilla Fortunatti, CF, Calero, K, Ji, M et al.. Nighttime Sleep Duration Is Associated With Length of Stay Outcomes Among Older Adult Survivors of Critical Illness. Dimens Crit Care Nurs. ;39 (3):145-154. doi: 10.1097/DCC.0000000000000411. PubMed PMID:32251163 .
  5. Loewen, OK, Maximova, K, Ekwaru, JP, Asbridge, M, Ohinmaa, A, Veugelers, PJ et al.. Adherence to Life-Style Recommendations and Attention-Deficit/Hyperactivity Disorder: A Population-Based Study of Children Aged 10 to 11 Years. Psychosom Med. 2020;82 (3):305-315. doi: 10.1097/PSY.0000000000000787. PubMed PMID:32251098 .
  6. Iannella, G, Maniaci, A, Magliulo, G, Cocuzza, S, La Mantia, I, Cammaroto, G et al.. Current challenges in the diagnosis and treatment of obstructive sleep apnea syndrome in the elderly. 2020; :. doi: 10.20452/pamw.15283. PubMed PMID:32250579 .
  7. Clemens, JQ, Wiseman, JB, Smith, AR, Amundsen, CL, Yang, CC, Bradley, MS et al.. Prevalence, subtypes, and correlates of nocturia in the symptoms of Lower Urinary Tract Dysfunction Research Network cohort. Neurourol. Urodyn. 2020; :. doi: 10.1002/nau.24338. PubMed PMID:32249998 .
  8. Scammell, TE, Luo, G, Borker, P, Sullivan, L, Biddle, K, Mignot, E et al.. Treatment of narcolepsy with natalizumab. Sleep. 2020; :. doi: 10.1093/sleep/zsaa050. PubMed PMID:32249922 .
  9. Fonseca, P, van Gilst, MM, Radha, M, Ross, M, Moreau, A, Cerny, A et al.. Automatic sleep staging using heart rate variability, body movements, and recurrent neural networks in a sleep disordered population. Sleep. 2020; :. doi: 10.1093/sleep/zsaa048. PubMed PMID:32249911 .
  10. Xu, Y, Li, X, Man, D, Su, X, A, G. iTRAQ based proteomics analysis on insomnia rats treated with Mongolian medical warm acupuncture. Biosci. Rep. 2020; :. doi: 10.1042/BSR20191517. PubMed PMID:32249904 .
  11. Hwang, SW, Chu, YC, Hwang, SR, Hwang, JH. Association of periodic limb movements during sleep and tinnitus in humans. Sci Rep. 2020;10 (1):5972. doi: 10.1038/s41598-020-62987-9. PubMed PMID:32249815 .
  12. Kisiel, MA, Zhou, X, Sundh, J, Ställberg, B, Lisspers, K, Malinovschi, A et al.. Data-driven questionnaire-based cluster analysis of asthma in Swedish adults. NPJ Prim Care Respir Med. 2020;30 (1):14. doi: 10.1038/s41533-020-0168-0. PubMed PMID:32249767 .
  13. Adler, I, Weidner, K, Eberhard-Gran, M, Garthus-Niegel, S. The Impact of Maternal Symptoms of Perinatal Insomnia on Social-emotional Child Development: A Population-based, 2-year Follow-up Study. Behav Sleep Med. 2020; :1-15. doi: 10.1080/15402002.2020.1746661. PubMed PMID:32249601 .
  14. Chen, XQ, Jiang, XM, Zheng, QX, Zheng, J, He, HG, Pan, YQ et al.. Factors associated with workplace fatigue among midwives in southern China: A multi-centre cross-sectional study. J Nurs Manag. 2020; :. doi: 10.1111/jonm.13015. PubMed PMID:32249450 .
  15. Leppänen, T, Kulkas, A, Töyräs, J, Myllymaa, S, Gadoth, N, Oksenberg, A et al.. Polysomnographic characteristics of severe obstructive sleep apnea vary significantly between hypertensive and normotensive patients of both genders. Sleep Breath. 2020; :. doi: 10.1007/s11325-020-02047-8. PubMed PMID:32249371 .
  16. Maugeri, A, Barchitta, M, Kunzova, S, Bauerova, H, Agodi, A, Vinciguerra, M et al.. The association of social and behavioral factors with dietary risks in adults: Evidence from the Kardiovize Brno 2030 study. Nutr Metab Cardiovasc Dis. 2020; :. doi: 10.1016/j.numecd.2020.02.009. PubMed PMID:32249142 .
  17. Abuan, MRA, Lin, WN, Hsin, LJ, Lee, LA, Fang, TJ, Chen, NH et al.. Tongue imaging during drug-induced sleep ultrasound in obstructive sleep apnea patients. Auris Nasus Larynx. 2020; :. doi: 10.1016/j.anl.2020.02.012. PubMed PMID:32248986 .
  18. Hall, KA, Singh, M, Mukherjee, S, Palmer, LJ. Physical Activity is Associated With Reduced Prevalence of Self-Reported Obstructive Sleep Apnea in a Large, General Population Cohort Study. J Clin Sleep Med. 2020; :. doi: 10.5664/jcsm.8456. PubMed PMID:32248899 .
  19. Kim, SY, Han, SR, Park, EJ, Yoo, H, Park, DS, Suh, S et al.. The Relationship Between Smartphone Overuse and Sleep in Younger Children: A Prospective Cohort Study. J Clin Sleep Med. 2020; :. doi: 10.5664/jcsm.8446. PubMed PMID:32248898 .
  20. MacGregor, AJ, Markwald, RR, Dougherty, AL, Seda, G. The Relationship Between Military Occupation and Diagnosed Insomnia Following Combat Deployment. J Clin Sleep Med. 2020; :. doi: 10.5664/jcsm.8444. PubMed PMID:32248897 .
  21. Hsu, N, Hsieh, C, Thomas, A, Chang, M. Obstructive Sleep Apnea due to Oromandibular Dystonia and Treated with Botulinum Toxin. J Clin Sleep Med. 2020; :. doi: 10.5664/jcsm.8454. PubMed PMID:32248896 .
  22. Johnson, DA, Sofer, T, Guo, N, Wilson, J, Redline, S. A Sleep Apnea Prediction Model Developed for African Americans, the Jackson Heart Sleep Study. J Clin Sleep Med. 2020; :. doi: 10.5664/jcsm.8452. PubMed PMID:32248895 .
  23. Eckert, MJ, McNaughton, BL, Tatsuno, M. Neural ensemble reactivation in rapid eye movement and slow-wave sleep coordinate with muscle activity to promote rapid motor skill learning. Philos. Trans. R. Soc. Lond., B, Biol. Sci. 2020;375 (1799):20190655. doi: 10.1098/rstb.2019.0655. PubMed PMID:32248776 .
  24. Benedict, TM, Keenan, PG, Nitz, AJ, Moeller-Bertram, T. Post-Traumatic Stress Disorder Symptoms Contribute to Worse Pain and Health Outcomes in Veterans With PTSD Compared to Those Without: A Systematic Review With Meta-Analysis. Mil Med. 2020; :. doi: 10.1093/milmed/usaa052. PubMed PMID:32248229 .
  25. Jarosz, M, Syed, S, Błachut, M, Badura Brzoza, K. Emotional distress and quality of life in allergic diseases. Wiad. Lek. 2020;73 (2):370-373. . PubMed PMID:32248177 .
Search PubMed

Search Terms: Insomnia, Narcolepsy, REM Sleep, Sleep Apnea, Sleep Quality