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Mutation of Coronavirus Is Significantly Increasing Its Ability To Infect

Following the emergence of SARS-CoV-2 in China in late 2019, and the rapid expansion of the COVID19 pandemic in 2020, questions about viral evolution have come tumbling after. Did SARS-CoV-2 evolve to become better adapted to humans? More infectious or transmissible? More deadly? Virus mutations can rise in frequency due to natural selection, random genetic drift, or features of recent epidemiology. As these forces can work in tandem, it’s often hard to differentiate when a virus mutation becomes common through fitness or by chance. It is even harder to determine if a single mutation will change the outcome of an infection, or a pandemic.

Korber et al. found that a SARS-CoV-2 variant in the spike protein, D614G, rapidly became dominant around the world. While clinical and in vitro data suggest that D614G changes the virus phenotype, the impact of the mutation on transmission, disease, and vaccine and therapeutic development are largely unknown.

source : https://www.cell.com/action/showPdf?pii=S0092-8674%2820%2930820-5

What you need to know about antibody mediated immunity to corona viruses

The duration and nature of immunity generated in response to SARS-CoV-2 infection is unknown. Many public health responses and modeled scenarios for COVID-19 outbreaks caused by SARSCoV-2 assume that infection results in an immune response that protects individuals from future infections or illness for some amount of time. The timescale of protection is a critical determinant
of the future impact of the pathogen. The presence or absence of protective immunity due to infection or vaccination (when available) will affect future transmission and illness severity. The dynamics of immunity and nature of protection are relevant to discussions surrounding therapeutic use of convalescent sera as well as efforts to identify individuals with protective immunity. Here, we review the scientific literature on antibody immunity to coronaviruses, including SARS-CoV-2 as well as the related SARS-CoV-1, MERS-CoV and human endemic coronaviruses (HCoVs).
We reviewed 1281 abstracts and identified 322 manuscripts relevant to 5 areas of focus: 1) antibody kinetics, 2) correlates of protection, 3) immunopathogenesis, 4) antigenic diversity and cross-reactivity, and 5) population seroprevalence. While studies of SARS-CoV-2 are necessary to determine immune responses to it, evidence from other coronaviruses can provide clues and guide future research.

Source : https://www.medrxiv.org/content/10.1101/2020.04.14.20065771v1.full.pdf

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Starting on October 11, 2023, Allergy Sleep & Lung Care (ASLC) will no longer be affiliated with GenesisCare due to their bankruptcy.

ASLC will be reopening as an independent practice at our Healthpark office on or after October 30, 2023.

Please don’t hesitate to reach out to us through any of the following contact channels:

Phone/text: 239-932-3023 / 239-437-6670

Email: 


 
A partir del 11 de octubre de 2023, Allergy Sleep & Lung Care (ASLC) ya no formará parte de GenesisCare debido a su quiebra.

ASLC volverá a abrir como una práctica independiente en nuestra oficina de Healthpark a partir del 30 de octubre de 2023 o después de esa fecha.

No dudes en ponerte en contacto con nosotros a través de cualquiera de los siguientes canales:

Teléfono/mensaje de texto: 239-932-3023 / 239-437-6670

Correo electrónico: 

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