Prevalence of depression and cognitive impairment and their inter-relationship and association with quality of life among older stroke survivors: the findings of a national survey in China
Zheng MR, Chen P, Feng Y, Zhang Q, Su Z, Cheung T, Ungvari GS, Ng CH and Xiang YT
Prevalence of depression and cognitive impairment and their inter-relationship and association with quality of life among older stroke survivors: the findings of a national survey in China
Zheng MR, Chen P, Feng Y, Zhang Q, Su Z, Cheung T, Ungvari GS, Ng CH and Xiang YT
Post-stroke depression (PSD) and post-stroke cognitive impairment (PSCI) are prevalent neuropsychiatric problems that are associated with high disability burden and low quality of life (QoL). This study explored the PSD-PSCI network, along with the interaction and association with QoL among Chinese older stroke survivors.
The impact of obstructive sleep apnea and the prognostic role of level III polysomnography at the onset of amyotrophic lateral sclerosis
Tavares M, Lúcio MJ, Borges J, Carriço F, Guimarães MJ and Drummond M
The impact of obstructive sleep apnea and the prognostic role of level III polysomnography at the onset of amyotrophic lateral sclerosis
Tavares M, Lúcio MJ, Borges J, Carriço F, Guimarães MJ and Drummond M
Sleep disturbances are considered an early manifestation of Amyotrophic lateral sclerosis (ALS). However, sleep-disordered breathing (SDB) in ALS remains underexplored. The primary outcome of this study is to describe the clinical, functional and polygraphic characteristics of ALS patients with baseline SDB and to compare those with and without obstructive sleep apnea (OSA) in level III polysomnography (PSG) at diagnosis. Secondary outcomes included identification of baseline factors predictive of non-invasive ventilation (NIV) initiation/death during follow-up and assessing the role of level III PSG performed at the initial clinical evaluation in ALS prognosis regarding timing to NIV initiation and death.
Effect of family-centred perioperative care for anaesthesia on the incidence of emergence delirium in children after surgery: a protocol for a randomised controlled trial in China
Chen J, Hu J, Zheng C, Song S, Yang C, Ye F and Li T
Effect of family-centred perioperative care for anaesthesia on the incidence of emergence delirium in children after surgery: a protocol for a randomised controlled trial in China
Chen J, Hu J, Zheng C, Song S, Yang C, Ye F and Li T
Emergence delirium (ED) stands out as a prevalent postoperative complication among paediatric patients, correlating with extended hospitalisation periods, escalated healthcare expenses and increased incidence of postoperative maladaptive behaviours (POMBs). Well-established pharmacological or non-pharmacological interventions demonstrating efficacy in reducing the occurrence of ED are notably absent. Therefore, this study aimed to assess the potential of family-centred perioperative care for anaesthesia (FPCA) in mitigating the incidence of ED in children compared with routine anaesthesia.
Computer vision syndrome and its relationship with sleep and fatigue in medical students
Garlock M, Speth M and McEchron M
Computer vision syndrome and its relationship with sleep and fatigue in medical students
Garlock M, Speth M and McEchron M
Safety profile of ramelteon from the perspective of physicians and pharmacists: a 20-year real-world pharmacovigilance analysis based on the FAERS database
Wu J, Zhou Y, Qiu L, Liu L, Wang F, Zhen L and Li N
Safety profile of ramelteon from the perspective of physicians and pharmacists: a 20-year real-world pharmacovigilance analysis based on the FAERS database
Wu J, Zhou Y, Qiu L, Liu L, Wang F, Zhen L and Li N
Ramelteon is the first selective melatonin receptor agonist approved by the FDA, demonstrating significant clinical value in improving sleep latency and sleep quality in patients with insomnia. However, its long-term adverse effects have not been fully evaluated. This study analyzes adverse events associated with ramelteon based on data from the FDA Adverse Event Reporting System (FAERS) database.
Characterizing healthcare resource utilization in two rare diseases (Kleefstra syndrome and SLC6A1 epileptic encephalopathy) using multimodal real-world data
Nichols CA, Nysetvold E, Jackson M, Tisdale A, Cutillo CM, Rego S, Cogell AN, Pace ND and Cotter K
Characterizing healthcare resource utilization in two rare diseases (Kleefstra syndrome and SLC6A1 epileptic encephalopathy) using multimodal real-world data
Nichols CA, Nysetvold E, Jackson M, Tisdale A, Cutillo CM, Rego S, Cogell AN, Pace ND and Cotter K
The cumulative economic burden of rare diseases surpasses that of common conditions, yet patterns of healthcare resource utilization (HRU) across rare diseases remain poorly characterized. This study leverages multimodal data collected during clinical care and through surveys to provide an in-depth evaluation of HRU across the disease journey of individuals with rare genetic diseases. Individuals with a confirmed diagnosis of Kleefstra syndrome (KS; n = 40) or SLC6A1 epileptic encephalopathy (SLC6A1; n = 30) were recruited. Structured and unstructured data were abstracted from participants' medical records. Encounters per person-year of follow-up were calculated and compared pre- and post-diagnosis. Parents/guardians completed surveys assessing the impact of the participant's diagnosis on their care.
Multi-dimensional sleep health and dementia risk: a prospective study in the UK Biobank
Huang T, Beydoun MA, Kianersi S, Redline S and Launer LJ
Multi-dimensional sleep health and dementia risk: a prospective study in the UK Biobank
Huang T, Beydoun MA, Kianersi S, Redline S and Launer LJ
The intricate interplay of various sleep characteristics may influence dementia risk through different pathogenic pathways. However, few studies have examined multi-dimensional sleep health in relation to dementia risk or explored potential etiologic heterogeneity by dementia subtypes.
Effectiveness of a smart management system in improving adherence and clinical outcomes of patients receiving peritoneal dialysis: a retrospective cohort analysis
Zeng Y, Yin Y, Deng J, Chen D, Deng L, Wang D, Huang Y, Peng J and Ye Z
Effectiveness of a smart management system in improving adherence and clinical outcomes of patients receiving peritoneal dialysis: a retrospective cohort analysis
Zeng Y, Yin Y, Deng J, Chen D, Deng L, Wang D, Huang Y, Peng J and Ye Z
Peritoneal dialysis (PD) is a widely used form of home dialysis. However, the efficacy of telehealth care in long-term management for PD patients remains unclear.
The mechanism of sleep quality's effect on academic burnout: examining the mediating role of perceived stress
Zakiei A, Khazaie H, Azadi M, Mohsenpour S and Komasi S
The mechanism of sleep quality's effect on academic burnout: examining the mediating role of perceived stress
Zakiei A, Khazaie H, Azadi M, Mohsenpour S and Komasi S
Given the importance of sleep during young adulthood and the role of students as key societal assets, investigating psychological factors related to stress and academic burnout is essential. Therefore, the present study aimed to examine the relationship between sleep quality and academic burnout, with the mediating role of perceived stress.
Disturbances in amino acid metabolism in obstructive sleep apnea-hypopnea syndrome: insights from a cross-sectional study
Huang J, Chen L, Zhong Y, Xie H, Chen M, Chen G and Lin Q
Disturbances in amino acid metabolism in obstructive sleep apnea-hypopnea syndrome: insights from a cross-sectional study
Huang J, Chen L, Zhong Y, Xie H, Chen M, Chen G and Lin Q
Obstructive sleep apnea-hypopnea syndrome (OSAHS) is an established risk factor for cardiovascular and metabolic diseases. This study aimed to explore the association between OSAHS severity and plasma amino acid profiles.
