FacebookTwitterLinkedIn
English English Spanish Spanish
Call us for an Appointment 239-437-6670
Latest Physician News2019-02-15T12:10:02+00:00

Latest in Sleep Medicine News

Epidemiology of Obstructive Sleep Apnea: a Population-based Perspective

Several population-based studies across various geographical regions and ethnic groups have established a high prevalence of OSA. This epidemic of OSA is closely related to the obesity epidemic—an important public health related condition facing adults globally. In the United States in 2004, the estimated prevalence of adult obesity, classified as a body mass index (BMI) over 30 kg/m2, was more than 30% and the prevalence of extreme obesity (BMI > 40 kg/m2) was 2.8% in men and 6.7% in women [1]. Associated health care expenditures in obese individuals is 36% higher than normal weight persons, and it has been estimated that up to 7% of the annual health care expenditures is related to obesity [2,3]. Obesity is a well-recognized risk factor for a variety of medical conditions such as OSA, type 2 diabetes, cardiovascular diseases, hyperlipidemia, metabolic syndrome, and nonalcoholic fatty liver disease.

Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2727690/

The Food and Drug Administration has approved pitolisant (Wakix) for excessive daytime sleepiness among patients with narcolepsy, according to a release from the drug’s developer.

The Food and Drug Administration has approved pitolisant (Wakix) for excessive daytime sleepiness among patients with narcolepsy, according to a release from the drug’s developer. Approval of this once-daily, selective histamine 3–receptor antagonist/inverse agonist was based on a pair of multicenter, randomized, double-blind, placebo-controlled studies that included a total of 261 patients. Patients in both studies experienced statistically significant improvements in excessive daytime sleepiness according to Epworth Sleepiness Scale scores.

Rates of adverse advents at or greater than 5% and more than double that of placebo included insomnia (6%), nausea (6%), and anxiety (5%). Patients with severe liver disease should not use pitolisant. Pitolisant has not been evaluated in patients under 18 years of age, and patients who are pregnant or planning to become pregnant are encouraged to enroll in a pregnancy exposure registry.

Source: https://www.mdedge.com/chestphysician/article/206754/sleep-medicine/fda-approves-wakix-excessive-daytime-sleepiness

Association of estimated sleep duration and naps with mortality and cardiovascular events: a study of 116 632 people from 21 countries

Abstract

Aims

To investigate the association of estimated total daily sleep duration and daytime nap duration with deaths and major cardiovascular events.

Methods and results

We estimated the durations of total daily sleep and daytime naps based on the amount of time in bed and self-reported napping time and examined the associations between them and the composite outcome of deaths and major cardiovascular events in 116 632 participants from seven regions. After a median follow-up of 7.8 years, we recorded 4381 deaths and 4365 major cardiovascular events. It showed both shorter (≤6 h/day) and longer (>8 h/day) estimated total sleep durations were associated with an increased risk of the composite outcome when adjusted for age and sex. After adjustment for demographic characteristics, lifestyle behaviours and health status, a J-shaped association was observed. Compared with sleeping 6–8 h/day, those who slept ≤6 h/day had a non-significant trend for increased risk of the composite outcome [hazard ratio (HR), 1.09; 95% confidence interval, 0.99–1.20]. As estimated sleep duration increased, we also noticed a significant trend for a greater risk of the composite outcome [HR of 1.05 (0.99–1.12), 1.17 (1.09–1.25), and 1.41 (1.30–1.53) for 8–9 h/day, 9–10 h/day, and >10 h/day, Ptrend < 0.0001, respectively]. The results were similar for each of all-cause mortality and major cardiovascular events. Daytime nap duration was associated with an increased risk of the composite events in those with over 6 h of nocturnal sleep duration, but not in shorter nocturnal sleepers (≤6 h).

Conclusion

Estimated total sleep duration of 6–8 h per day is associated with the lowest risk of deaths and major cardiovascular events. Daytime napping is associated with increased risks of major cardiovascular events and deaths in those with >6 h of nighttime sleep but not in those sleeping ≤6 h/night.

Author:
Chuangshi Wang, Shrikant I Bangdiwala, Sumathy Rangarajan, Scott A Lear,Khalid F AlHabib, Viswanathan Mohan, Koon Teo, Paul Poirier, Lap Ah TSE, Zhiguang Liu, Annika Rosengren, Rajesh Kumar, Patricio Lopez-Jaramillo, Khalid Yusoff, Nahed Monsef,Vijayakumar Krishnapillai, Noorhassim Ismail, Pamela Seron, Antonio L Dans,Lanthé Kruger, Karen Yeates, Lloyd Leach, Rita Yusuf, Andres Orlandini, Maria Wolyniec,Ahmad Bahonar, Indu Mohan, Rasha Khatib, Ahmet Temizhan, Wei Li,Salim Yusuf

Source: https://academic.oup.com/eurheartj/article-abstract/40/20/1620/5229545

Latest in Sleep Medicine Research

  1. Chu, G, Suthers, B, Paech, GM, Eyeington, L, Gunawardhana, L, Palazzi, K et al.. Feasibility of Online Haemodiafiltration in Sleep Apnoea: A Randomized Crossover Study. Blood Purif. 2020; :1-10. doi: 10.1159/000505572. PubMed PMID:31982882 .
  2. Ali, W, Gao, G, Bakris, GL. Improved Sleep Quality Improves Blood Pressure Control among Patients with Chronic Kidney Disease: A Pilot Study. Am. J. Nephrol. 2020; :1-5. doi: 10.1159/000505895. PubMed PMID:31982868 .
  3. Paardekooper, D, Thayer, Z, Miller, L, Nikpour, A, Gascoigne, MB. Group-based cognitive behavioral therapy program for improving poor sleep quality and quality of life in people with epilepsy: A pilot study. Epilepsy Behav. 2020;104 (Pt A):106884. doi: 10.1016/j.yebeh.2019.106884. PubMed PMID:31982831 .
  4. Tan-MacNeill, KM, Smith, IM, Weiss, SK, Johnson, SA, Chorney, J, Constantin, E et al.. An eHealth insomnia intervention for children with neurodevelopmental disorders: Results of a usability study. Res Dev Disabil. 2020;98 :103573. doi: 10.1016/j.ridd.2020.103573. PubMed PMID:31982826 .
  5. Wei, S, Smits, MG, Tang, X, Kuang, L, Meng, H, Ni, S et al.. Efficacy and safety of melatonin for sleep onset insomnia in children and adolescents: a meta-analysis of randomized controlled trials. Sleep Med. 2019;68 :1-8. doi: 10.1016/j.sleep.2019.02.017. PubMed PMID:31982807 .
  6. Malow, BA, Findling, RL, Schroder, CM, Maras, A, Breddy, J, Nir, T et al.. Sleep, Growth, and Puberty After Two Years of Prolonged-Release Melatonin in Children With Autism Spectrum Disorder. J Am Acad Child Adolesc Psychiatry. 2020; :. doi: 10.1016/j.jaac.2019.12.007. PubMed PMID:31982581 .
  7. Schreijenberg, M, Chiarotto, A, Mauff, KAL, Christine Lin, CW, Maher, CG, Koes, BW et al.. Inferential reproduction analysis demonstrated that 'Paracetamol for Acute Low Back Pain' trial conclusions were reproducible. J Clin Epidemiol. 2020; :. doi: 10.1016/j.jclinepi.2020.01.010. PubMed PMID:31982540 .
  8. Shen, Y, Shen, Y, Dong, ZF, Pan, PL, Shi, HC, Liu, CF et al.. Obstructive sleep apnea in Parkinson's disease: a study in 239 Chinese patients. Sleep Med. 2019;67 :237-243. doi: 10.1016/j.sleep.2019.11.1251. PubMed PMID:31981970 .
  9. Suzuki, K, Suzuki, S, Ishii, Y, Okamura, M, Matsubara, T, Fujita, H et al.. Plasma prostaglandin D2 synthase levels in sleep and neurological diseases. J. Neurol. Sci. 2020;411 :116692. doi: 10.1016/j.jns.2020.116692. PubMed PMID:31981928 .
  10. Bourjeily, G, Danilack, VA, Bublitz, MH, Muri, J, Rosene-Montella, K, Lipkind, H et al.. Maternal obstructive sleep apnea and neonatal birth outcomes in a population based sample. Sleep Med. 2019;66 :233-240. doi: 10.1016/j.sleep.2019.01.019. PubMed PMID:31981755 .
  11. Feng, YS, Yang, SD, Tan, ZX, Wang, MM, Xing, Y, Dong, F et al.. The benefits and mechanisms of exercise training for Parkinson's disease. Life Sci. 2020; :117345. doi: 10.1016/j.lfs.2020.117345. PubMed PMID:31981631 .
  12. Kawabata, N, Hata, A, Aoki, T. Effect of aromatherapy massage on quality of sleep in the palliative care ward: a randomized controlled trial. J Pain Symptom Manage. 2020; :. doi: 10.1016/j.jpainsymman.2020.01.003. PubMed PMID:31981597 .
  13. Andrade, A, Kuah, CY, Martin-Lopez, JE, Chua, S, Shpadaruk, V, Sanclemente, G et al.. Interventions for chronic pruritus of unknown origin. Cochrane Database Syst Rev. 2020;1 :CD013128. doi: 10.1002/14651858.CD013128.pub2. PubMed PMID:31981369 .
  14. Punjwani, S, Parpio, Y, Barolia, R, Shamim, S, Asad, N. Psychological distress and its associated factors among informal care givers of disabled young adults with traumatic brain injuries. J Pak Med Assoc. 2020;70(Suppl 1) (2):S15-S19. . PubMed PMID:31981329 .
  15. Cao, B, Fan, Z, Zhang, Y, Li, T. Independent association of severity of obstructive sleep apnea with lipid metabolism of atherogenic index of plasma (AIP) and apoB/apoAI ratio. Sleep Breath. 2020; :. doi: 10.1007/s11325-020-02016-1. PubMed PMID:31981042 .
  16. Kısabay Ak, A, Batum, M, Göktalay, T, Mayali, H, Kurt, E, Selçuki, D et al.. Evaluation of retinal fiber thickness and visual pathways with optic coherence tomography and pattern visual evoked potential in different clinical stages of obstructive sleep apnea syndrome. Doc Ophthalmol. 2020; :. doi: 10.1007/s10633-020-09749-0. PubMed PMID:31981012 .
  17. Firincioglulari, M, Aksoy, S, Orhan, K, Oz, U, Rasmussen, F. Comparison of anterior mandible anatomical characteristics between obstructive sleep apnea patients and healthy individuals: a combined cone beam computed tomography and polysomnographic study. Eur Arch Otorhinolaryngol. 2020; :. doi: 10.1007/s00405-020-05805-2. PubMed PMID:31980885 .
  18. Rojo-Wissar, DM, Owusu, JT, Nyhuis, C, Jackson, CL, Urbanek, JK, Spira, AP et al.. Parent-child relationship quality and sleep among adolescents: Modification by race/ethnicity. Sleep Health. 2020; :. doi: 10.1016/j.sleh.2019.12.010. PubMed PMID:31980401 .
  19. Vanfleteren, LE, Beghe, B, Andersson, A, Hansson, D, Fabbri, LM, Grote, L et al.. Multimorbidity in COPD, does sleep matter?. Eur. J. Intern. Med. 2020; :. doi: 10.1016/j.ejim.2019.12.032. PubMed PMID:31980328 .
  20. Okauchi, H, Higo-Yamamoto, S, Sowa, T, Oike, H, Yamamoto, S, Wada, N et al.. Chronically skipping breakfast impairs hippocampal memory-related gene expression and memory function accompanied by reduced wakefulness and body temperature in mice. Biochem. Biophys. Res. Commun. 2020; :. doi: 10.1016/j.bbrc.2020.01.077. PubMed PMID:31980181 .
  21. Koushik, Y, Hs, K. Electronic gadget Screen-time, Sleep Quality & Quantity and Academic performance in Medical Students. J Assoc Physicians India. 2020;68 (1):102. . PubMed PMID:31979948 .
  22. Bhatia, M. Development and Validation of a Questionnaire to Assess Insomnia in Indian Setting. J Assoc Physicians India. 2020;68 (1):68. . PubMed PMID:31979680 .
  23. Rao, A. Study of Obstructive Sleep Apnoea in Patients with Hypertension. J Assoc Physicians India. 2020;68 (1):58. . PubMed PMID:31979625 .
  24. Singh, A, Chaudhary, SC, Gupta, KK. Prevalence of Obstructive Sleep Apnea in Diabetic patients. J Assoc Physicians India. 2020;68 (1):50. . PubMed PMID:31979559 .
  25. Yuan, M, Fu, H, Liu, R, Fang, Y. Effect of Frequency of Exercise on Cognitive Function in Older Adults: Serial Mediation of Depression and Quality of Sleep. Int J Environ Res Public Health. 2020;17 (3):. doi: 10.3390/ijerph17030709. PubMed PMID:31979038 .
Search PubMed

Search Terms: Insomnia, Narcolepsy, REM Sleep, Sleep Apnea, Sleep Quality

LUNGCARE.NET