Banxia Shumi Decoction Alleviates PCPA-Induced Insomnia and Regulates ADAM10 Expression via Melatonin Signaling in Rats
Guo B, Tang Y, Zhang Y, Wu Y and Gao R
Banxia Shumi Decoction Alleviates PCPA-Induced Insomnia and Regulates ADAM10 Expression via Melatonin Signaling in Rats
Guo B, Tang Y, Zhang Y, Wu Y and Gao R
Insomnia is a pathological sleep disorder marked by persistent sleep-onset difficulties. This study explored the therapeutic effects and underlying mechanism of Banxia Shumi Decoction (BXSMD) in treating insomnia.
Gabapentin-Induced Severe Vivid Nightmares: A Case Series and Brief Review
Hasoon J, Nguyen A, Safabakhsh NA, Viswanath O and Robinson CL
Gabapentin-Induced Severe Vivid Nightmares: A Case Series and Brief Review
Hasoon J, Nguyen A, Safabakhsh NA, Viswanath O and Robinson CL
Gabapentin is widely prescribed for neuropathic and radicular pain syndromes. While somnolence and dizziness are well-recognized adverse effects, severe vivid nightmares may constitute an underreported psychiatric side effect that can significantly impair quality of life and treatment adherence. We present two cases of gabapentin-induced severe vivid nightmares in patients treated for spinal pain syndromes. Management strategies included medication discontinuation and transition to pregabalin. Both patients experienced resolution of nightmares following intervention. This report reviews the existing literature on gabapentin's effects on sleep architecture and discusses potential mechanisms, clinical implications, and management approaches.
Diagnosis-related handoffs for inter-facility transfers to the pediatric intensive care unit
Pantekidis I, Pandiyan P, Singh H, Landrigan CP and Cifra CL
Diagnosis-related handoffs for inter-facility transfers to the pediatric intensive care unit
Pantekidis I, Pandiyan P, Singh H, Landrigan CP and Cifra CL
Inter-facility transfers to the pediatric intensive care unit (PICU) increase the risk of patient harm from communication breakdowns. We previously developed I-PASS-to-PICU, a structured inter-facility handoff program to improve information exchange during these transitions. However, it was not designed to optimize communication related to diagnosis (diagnostic handoff). This exploratory study evaluated how well I-PASS-to-PICU facilitated inter-facility diagnostic handoffs.
Visual snow syndrome as a neuropsychiatric network disorder: clinical features, mechanisms, and therapeutic perspectives
Huang Q, Wang J, Zhao L, Yu X, Wang W, Wang Z and Liu Y
Visual snow syndrome as a neuropsychiatric network disorder: clinical features, mechanisms, and therapeutic perspectives
Huang Q, Wang J, Zhao L, Yu X, Wang W, Wang Z and Liu Y
Visual Snow Syndrome (VSS) is a neurological condition characterized by the persistent perception of dynamic, flickering, dot-like visual disturbances across the entire visual field, resembling television static. Increasing evidence indicates that VSS is frequently accompanied by a broad spectrum of psychiatric symptoms, including anxiety, depression, depersonalization, fatigue, and sleep disturbances, all of which substantially impair quality of life. Although the pathogenesis of VSS remains incompletely understood, Current evidence increasingly suggests that VSS may represent a multisystem neuropsychiatric network disorder involving visual cortical hyperexcitability, thalamocortical dysrhythmia, widespread abnormalities in functional connectivity, and limbic system dysfunction. Psychiatric symptoms may partly reflect intrinsic neurobiological mechanisms of the syndrome rather than being solely secondary psychological reactions to chronic visual disturbances. Current pharmacological therapies generally show limited efficacy. Preliminary evidence suggests that non-pharmacological approaches, including neuromodulation, tinted lenses, and mindfulness-based interventions, may offer therapeutic potential with relatively favorable tolerability, although larger controlled studies are still required. Future research should adopt multidisciplinary strategies integrating neurology, psychiatry, neuroimaging, and genetics to further elucidate the mechanisms underlying VSS and facilitate the development of precision diagnostic and therapeutic approaches.
Shank3 mutation disrupts the molecular signature of sleepiness across development
Wald E, Medina E, Ottaway C, Muheim CM, Ford K, Patterson TW, Singletary K, Ingiosi A and Peixoto L
Shank3 mutation disrupts the molecular signature of sleepiness across development
Wald E, Medina E, Ottaway C, Muheim CM, Ford K, Patterson TW, Singletary K, Ingiosi A and Peixoto L
Background Sleep problems are common in autism, emerge early in life and reduce quality of life, yet the mechanistic link between autism and poor sleep remains unclear. Human and rodent data indicate that difficulty falling asleep is a core feature of autistic insomnia, pointing to impaired responses to sleepiness as the underlying cause. We previously showed that adult mice carrying a mutation in the high-confidence autism gene (Shank3 ) recapitulate this insomnia phenotype and struggle to respond to sleepiness after acute sleep deprivation. Here, we used Shank3 mice to examine the molecular basis of sleepiness and how this autism-associated mutation alters it to inform understanding of sleep problems in autistic individuals.
Sex Differences in the Prevalence and Correlates of Sleep Disturbance Among Indonesian Stroke Survivors: A Population-Based Study of 7,147 Individuals
Susanty S, Apriliyasari RW, Chiu HY, Rashid RBA, Prasetya EC, Phanphairoj K, Sujarwadi M and Hasan F
Sex Differences in the Prevalence and Correlates of Sleep Disturbance Among Indonesian Stroke Survivors: A Population-Based Study of 7,147 Individuals
Susanty S, Apriliyasari RW, Chiu HY, Rashid RBA, Prasetya EC, Phanphairoj K, Sujarwadi M and Hasan F
Sleep disturbance is a prevalent issue among those who have experienced a stroke. The impact of gender on the prevalence of sleep disturbance within Asian stroke populations remains ambiguous. This research seeks to examine the prevalence of sleep disturbance among stroke survivors in Indonesia.
Component- and dimension-level network associations between sleep quality and health-related quality of life in older adults with hypertension
Sun X, Guo Y, Ding B and Hu J
Component- and dimension-level network associations between sleep quality and health-related quality of life in older adults with hypertension
Sun X, Guo Y, Ding B and Hu J
Older adults with hypertension commonly experience poor sleep quality and reduced health-related quality of life (HRQoL). Previous studies have mainly examined these associations using total scores, providing limited insight into interactions between specific symptom dimensions. This study aimed to construct a component- and dimension-level network linking sleep quality and HRQoL and to compare network differences across depressive-symptom status.
Observational Assessment of the Effect of Sleep Bruxism on Oxyhaemoglobin Saturation:A Preliminary Study
Palinkas M, Siéssere S and Regalo SCH
Observational Assessment of the Effect of Sleep Bruxism on Oxyhaemoglobin Saturation:A Preliminary Study
Palinkas M, Siéssere S and Regalo SCH
Sleep bruxism, characterized by involuntary muscle activity and classified into phasic and tonic patterns, warrants analysis with respect to physiological parameters, as this could aid in understanding its broader health implications. This observational study aimed to compare oxyhaemoglobin saturation between subjects with and without sleep bruxism.
Sleep Quality and Depressive Symptoms Among Pregnant Women in the Third Trimester: A Cross-Sectional Latent Profile and Network Analysis
Guan Y, Shen Z, Du Q, Tan Q and Tong X
Sleep Quality and Depressive Symptoms Among Pregnant Women in the Third Trimester: A Cross-Sectional Latent Profile and Network Analysis
Guan Y, Shen Z, Du Q, Tan Q and Tong X
To identify heterogeneous sleep-quality profiles among pregnant women in the third trimester and characterize profile-specific sleep quality-depressive symptom network structures.
The Role and Diagnostic Accuracy of Artificial Intelligence in Pulmonary Function Tests: A Systematic Review
Orpwood T and Soica IL
The Role and Diagnostic Accuracy of Artificial Intelligence in Pulmonary Function Tests: A Systematic Review
Orpwood T and Soica IL
The rapid advancement of artificial intelligence (AI) has highlighted its potential as a supportive tool in pulmonary function test (PFT) interpretation given the inherent biological variation, inter-rater variability, lack of confidence in result interpretation and restricted access within resource-constrained settings. This study aims to systematically review the published literature on the diagnostic accuracy of AI-based interpretation of PFTs and evaluate its implications for current and future clinical practice in healthcare. After screening, forty-seven publications met the inclusion criteria and were analysed to create a narrative summary. Four main over-arching themes were identified from the available literature. AI appears to consistently outperform non-specialists in diagnostic accuracy of PFTs and showed a synergistic effect when used as an adjunct in both specialist and non-specialist settings. Using AI software also had greater diagnostic accuracy than clinicians when presented with suboptimal or limited clinical information and investigations. It was also observed that the implementation of AI can address the issue of inter-rater variability by giving more consultant interpretations. Chronic obstructive pulmonary disease diagnosis saw the greatest accuracy with other conditions such as obstructive sleep apnoea showing limited evidence for the introduction of AI as a diagnostic tool. The evidence suggests that AI has the potential to play a significant role in the future of healthcare but should be used as an adjunctive tool as opposed to an independent diagnostic decision maker. One such way it could be utilised is as a triage/screening tool to help bridge the gap between primary and secondary care.
