Crosstalk between gastrointestinal tract disorders and obstructive sleep apnea
Jian S, Liu J, He M, Liu B, Liu K, Zang C, Su X, Zhang Y and Yi M
Crosstalk between gastrointestinal tract disorders and obstructive sleep apnea
Jian S, Liu J, He M, Liu B, Liu K, Zang C, Su X, Zhang Y and Yi M
Clinical studies suggested associations between obstructive sleep apnea (OSA) and gastrointestinal tract disorders. This study aims to investigate the genetic causal relationship between OSA and gastrointestinal tract disorders, specifically gastroesophageal reflux disease (GERD) and inflammatory bowel disease (IBD).
The relationship between sleep quality and fear of COVID-19, anxiety, personality traits in working women
Keskin G, Gümüşsoy S and Taşdemir Yiğitoğlu G
The relationship between sleep quality and fear of COVID-19, anxiety, personality traits in working women
Keskin G, Gümüşsoy S and Taşdemir Yiğitoğlu G
Disasters such as the COVID-19 pandemic have serious traumatic effects on people, who may experience sleep problems, anxiety, and fear in the face of such a stressor.
Orexin and Sleep Disturbances in Alpha-Synucleinopathies: a Systematic Review
Raheel K, See QR, Munday V, Fakhroo B, Ivanenko O, Salvatelli ML, Mutti C, Goadsby PJ, Delogu A, Naismith SL, Holland P, Parrino L, Chaudhuri KR and Rosenzweig I
Orexin and Sleep Disturbances in Alpha-Synucleinopathies: a Systematic Review
Raheel K, See QR, Munday V, Fakhroo B, Ivanenko O, Salvatelli ML, Mutti C, Goadsby PJ, Delogu A, Naismith SL, Holland P, Parrino L, Chaudhuri KR and Rosenzweig I
Sleep disturbances are amongst most frequent non-motor symptoms of Parkinson's Disease (PD), and they are similarly frequently reported in other alpha-syncleinopathies, such as Dementia with Lewy Bodies (DLB) and Multiple System Atrophy (MSA). More recently, the orexin system has been implicated in control of arousal based on salient environmental set points, and its dysregulation in sleep issues in alpha-synucleinopathies suggested by the findings from the translational animal models. However, its role in the patients with alpha-synucleinopathies remains unclear. We thus set to systematically review, and to critically assess, contemporary evidence on the association of the orexinergic system and sleep disturbances in alpha-synucleinopathies. In this systematic review, studies investigating orexin and sleep in alpha-synucleinopathies (Rapid Eye Movement (REM) Behaviour Disorder (RBD), Parkinson's Disease (PD), Dementia with Lewy Bodies (DLB), Multiple System Atrophy (MSA)) were identified using electronic database searches of PubMed, Web of Science and PsychINFO using MeSH terms, keywords, and title words such as "Alpha-synucleinopathies" AND "Orexin" AND "Sleep Disturbances".
Exploring emotional distress symptom clusters in young adults with childhood traumatic brain injury
Botchway-Commey E, Ryan PN, Anderson V and Catroppa C
Exploring emotional distress symptom clusters in young adults with childhood traumatic brain injury
Botchway-Commey E, Ryan PN, Anderson V and Catroppa C
Depression, anxiety, and stress are persistent and co-occurring symptoms in survivors of childhood traumatic brain injury (TBI), and often impact on health-related quality of life (HRQoL). This paper explored emotional distress symptom clusters and associated factors in young adults with childhood TBI.
Gray matter volume alterations in de novo Parkinson's disease: A mediational role in the interplay between sleep quality and anxiety
He G, Huang X, Sun H, Xing Y, Gu S, Ren J, Liu W and Lu M
Gray matter volume alterations in de novo Parkinson's disease: A mediational role in the interplay between sleep quality and anxiety
He G, Huang X, Sun H, Xing Y, Gu S, Ren J, Liu W and Lu M
Parkinson's disease (PD) is increasingly recognized for its non-motor symptoms, among which emotional disturbances and sleep disorders frequently co-occur. The commonality of neuroanatomical underpinnings for these symptoms is not fully understood. This study is intended to investigate the differences in gray matter volume (GMV) between PD patients with anxiety (A-PD) and those without anxiety (NA-PD). Additionally, it seeks to uncover the interplay between GMV variations and the manifestations of anxiety and sleep quality.
Modulation of sleep/wake patterns by gephyrin phosphorylation status
Tsai YC, ElGrawani W, Muheim C, Spinnler A, Campbell BFN, Lasic D, Hleihil M, Brown SA and Tyagarajan SK
Modulation of sleep/wake patterns by gephyrin phosphorylation status
Tsai YC, ElGrawani W, Muheim C, Spinnler A, Campbell BFN, Lasic D, Hleihil M, Brown SA and Tyagarajan SK
Sleep/wake cycles intricately shape physiological activities including cognitive brain functions, yet the precise molecular orchestrators of sleep remain elusive. Notably, the clinical impact of benzodiazepine drugs underscores the pivotal role of GABAergic neurotransmission in sleep regulation. However, the specific contributions of distinct GABA receptor subtypes and their principal scaffolding protein, gephyrin, in sleep dynamics remain unclear. The evolving role of synaptic phospho-proteome alterations at excitatory and inhibitory synapses suggests a potential avenue for modulating gephyrin and, consequently, GABARs for sleep through on-demand kinase recruitment. Our study unveils the distinctive roles of two prevalent GABA receptor subtypes, α1- and α2-GABARs, in influencing sleep duration and electrical sleep activity. Notably, the absence of α1-GABARs emerges as central in sleep regulation, manifesting significant alterations in both non-rapid eye movement (NREM) and rapid eye movement (REM) sleep during dark or active phases, accompanied by altered electroencephalogram (EEG) patterns across various frequencies. Gephyrin proteomics analysis reveals sleep/wake-dependent interactions with a repertoire of known and novel kinases. Crucially, we identify the regulation of gephyrin interaction with ERK1/2, and phosphorylations at serines 268 and 270 are dictated by sleep/wake cycles. Employing AAV-eGFP-gephyrin or its phospho-null variant (S268A/S270A), we disrupt sleep either globally or locally to demonstrate gephyrin phosphorylation as a sleep regulator. In summary, our findings support the local cortical sleep hypothesis and we unveil a molecular mechanism operating at GABAergic synapses, providing critical insights into the intricate regulation of sleep.
Ageing-related modification of sleep and breathing in orexin-knockout narcoleptic mice
Bastianini S, Alvente S, Berteotti C, Lo Martire V, Matteoli G, Miglioranza E, Silvani A and Zoccoli G
Ageing-related modification of sleep and breathing in orexin-knockout narcoleptic mice
Bastianini S, Alvente S, Berteotti C, Lo Martire V, Matteoli G, Miglioranza E, Silvani A and Zoccoli G
Narcolepsy type-1 (NT1) is a lifelong sleep disease, characterised by impairment of the orexinergic system, with a typical onset during adolescence and young adulthood. Since the wake-sleep cycle physiologically changes with ageing, this study aims to compare sleep patterns between orexin-knockout (KO) and wild type (WT) control mice at different ages. Four groups of age-matched female KO and WT mice (16 weeks of age: 8 KO-YO and 9 WT-YO mice; 87 weeks of age: 13 KO-OLD and 12 WT-OLD mice) were implanted with electrodes for discriminating wakefulness, rapid-eye-movement sleep (REMS), and non-REMS (NREMS). Mice were recorded for 48 h in their home cages and for 7 more hours into a plethysmographic chamber to characterise their sleep-breathing pattern. Regardless of orexin deficiency, OLD mice spent less time awake and had fragmentation of this behavioural state showing more bouts of shorter length than YO mice. OLD mice also had more NREMS bouts and less frequent NREMS apneas than YO mice. Regardless of age, KO mice showed cataplexy-like episodes and shorter REMS latency than WT controls and had a faster breathing rate and an increased minute ventilation during REMS. KO mice also had more wakefulness, NREMS and REMS bouts, and a shorter mean length of wakefulness bouts than WT controls. Our experiment indicated that the lack of orexins as well as ageing importantly modulate the sleep and breathing phenotype in mice. The narcoleptic phenotype caused by orexin deficiency in female mice was substantially preserved with ageing.
Overnight Monitoring Criteria for Children with Obstructive Sleep-Disordered Breathing After Tonsillectomy: Revisited
Jáuregui EJ, Diala O, Rove KO, Hoefner-Notz R, Tong S, Nguyen T and Friedman NR
Overnight Monitoring Criteria for Children with Obstructive Sleep-Disordered Breathing After Tonsillectomy: Revisited
Jáuregui EJ, Diala O, Rove KO, Hoefner-Notz R, Tong S, Nguyen T and Friedman NR
Previous studies indicate children who pass an Asleep Room Air Challenge (AsRAC) do not have significant postoperative adverse respiratory events after adenotonsillectomy (T&A). Subsequently, we revised our overnight monitoring (OM) criteria, allowing patients with an obstructive apnea/hypopnea index (OAHI) ≤20 or nonsevere obesity (Class I) to be considered for same-day surgery (SDS) if they passed an AsRAC. Our hypothesis is that our modified OM criteria would not increase the return visits or readmission rates for patients undergoing SDS within 48 h or 15 days of T&A.
3D Genial Tubercle Anatomic Considerations in Genioglossus Advancement Surgery
Punjabi N, Vacaru A and Inman JC
3D Genial Tubercle Anatomic Considerations in Genioglossus Advancement Surgery
Punjabi N, Vacaru A and Inman JC
To qualitatively describe variation in morphology of the genial tubercle and quantify the spatial relationship between the tubercle and genioglossus muscle.
Later ("evening") circadian preference is associated with poorer executive, academic, and attentional functioning in adolescents with and without ADHD
Becker SP, Brown A, Langberg JM and Beebe DW
Later ("evening") circadian preference is associated with poorer executive, academic, and attentional functioning in adolescents with and without ADHD
Becker SP, Brown A, Langberg JM and Beebe DW
Adolescents vary considerably in their circadian phase preference; those with greater "eveningness" (also known as "night owls") have later bedtimes, wake times, and peak arousal compared to those with greater "morningness." Prior research suggests that (a) greater eveningness is associated with worse academic, executive, and attentional functioning; and (b) adolescents with attention-deficit/hyperactivity disorder (ADHD) tend to be high in eveningness and to have deficits in these school-related constructs. However, few studies have examined circadian preference alongside two potential confounds-sleep duration and sleep quality-as predictors of daytime functioning, or whether the strength of associations differs across adolescents with and without ADHD.