Abnormal resting-state EEG microstates correlate with objective sleep parameters in insomnia disorder
Wu Q, Weng L and Lei X
Abnormal resting-state EEG microstates correlate with objective sleep parameters in insomnia disorder
Wu Q, Weng L and Lei X
Insomnia is a common sleep disorder, and Electroencephalogram (EEG) microstates, which mirror transient cerebral cortical functional activity, are linked to sleep disorder pathophysiology. The microstate characteristics in insomnia patients and correlations with objective sleep parameters remain to be further explored.
Safety and efficacy of high-current tTIS targeting left sgACC for major depressive disorder: A randomized, double-blind, sham-controlled trial
Wang M, Wu W, Zheng Q, Zhou H, Ren J, Gou H, Meng X, Cui G, Sun J, Zhou J, Chen X, Guo J, Li S, He Z, Ge D, Wang G, Yuan Q, Jiao D, Yu X, Wang B, Zhang M, Chang C, Zeng GQ and Zhang X
Safety and efficacy of high-current tTIS targeting left sgACC for major depressive disorder: A randomized, double-blind, sham-controlled trial
Wang M, Wu W, Zheng Q, Zhou H, Ren J, Gou H, Meng X, Cui G, Sun J, Zhou J, Chen X, Guo J, Li S, He Z, Ge D, Wang G, Yuan Q, Jiao D, Yu X, Wang B, Zhang M, Chang C, Zeng GQ and Zhang X
Major depressive disorder (MDD) is a leading cause of disability, and non-invasive stimulation of deep brain circuits such as the subgenual anterior cingulate cortex (sgACC) remains challenging. This randomized, double-blind, sham-controlled trial recruits 96 adults with moderate-to-severe MDD who received 10 sessions of 2 mA low-current, 15 mA high-current, or sham transcranial temporal interference stimulation (tTIS) targeting the left sgACC. The high-current group shows significantly greater reductions in depressive symptoms (17-item Hamilton Depression Rating Scale [HDRS-17] score) post-treatment and at 1-month follow-up compared with sham and outperforms the low-current group post-treatment. Exploratory Pittsburgh Sleep Quality Index (PSQI) analyses suggest improved sleep quality in both active groups, whereas anxiety outcomes show no intergroup differences. High-current tTIS is safe and well tolerated, with only transient tingling. These findings provide preliminary evidence that sgACC-targeted tTIS relieves depressive symptoms safely, with more robust short-to medium-term effects observed under the 15 mA protocol. This trial registers on Chictr.org.cn (ChiCTR2400094971).
A comparative study of modified suanzaoren decoction versus estazolam in chronic insomnia disorder: Clinical outcomes and thalamocortical network changes
Wang R, Han Y, Chen L, Lv D, Yao P, Guo Z and Guo W
A comparative study of modified suanzaoren decoction versus estazolam in chronic insomnia disorder: Clinical outcomes and thalamocortical network changes
Wang R, Han Y, Chen L, Lv D, Yao P, Guo Z and Guo W
Chronic insomnia disorder (CID) is associated with widespread abnormalities in thalamic functional connectivity (FC). For CID patients with the yin-deficiency and fire-excess syndrome, Modified Suanzaoren Decoction (MSZRD) and estazolam are common treatments, but their longitudinal associations with thalamic networks remain unclear. This study was a non-randomized, patient-preference controlled trial. Eighty-two CID patients with yin-deficiency and fire-excess syndrome received a 6-week treatment with either MSZRD or estazolam based on preference. Additionally, 54 healthy controls (HCs) were recruited for baseline comparison. Clinical scales, polysomnography, and resting-state fMRI data were collected pre- and post-treatment. Using the Human Brainnetome Atlas, the thalamus was parcellated into eight subregions. We examined baseline group differences and longitudinal FC changes, and identified genes associated with the baseline FC alterations for enrichment analysis. At baseline, CID patients showed significantly increased FC in pathways involving the medial pre-frontal thalamus, posterior parietal thalamus, lateral pre-frontal thalamus, and caudal temporal thalamus with multiple cortical regions. After treatment, the MSZRD group showed greater improvement than the estazolam group on subjective and objective measures. While FC decreased in the MSZRD group between the left occipital thalamus and right middle frontal gyrus, and between the right occipital thalamus and right angular gyrus, it increased in the estazolam group for these connections. Enrichment analysis of genes associated with baseline FC alterations identified pathways related to synaptic organization, cytoskeletal stability, and metabolism. These findings provide preliminary evidence that CID is associated with enhanced thalamocortical connectivity consistent with the thalamus-centric hyperarousal model, and that MSZRD and estazolam show different clinical and neural correlates. However, due to the non-randomized design and baseline FC differences, these findings are hypothesis-generating and require validation in future randomized mechanistic studies.
The relationship between sleep quality and pain, fatigue, and mood in individuals with lipedema
Kesiktaş N, Ersoy S and Şirin Ahısha B
The relationship between sleep quality and pain, fatigue, and mood in individuals with lipedema
Kesiktaş N, Ersoy S and Şirin Ahısha B
ObjectiveThis study aimed to comparatively evaluate sleep quality in individuals with lipedema and healthy controls. In addition, the relationships between sleep quality and depression, anxiety, fatigue, and clinical parameters were investigated.MethodsThis cross-sectional study included 30 women with lipedema and 30 healthy female controls aged 18-75 years. Pain severity in individuals with lipedema was assessed using the Visual Analog Scale (VAS). Lipedema stage, comorbidities, and symptom duration were also recorded. Sleep quality was evaluated using the Pittsburgh Sleep Quality Index (PSQI), depressive and anxiety-related symptoms were assessed using the Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI), and fatigue severity was evaluated using the Fatigue Severity Scale (FSS).ResultsIndividuals with lipedema had significantly higher BDI, BAI, and FSS scores than controls (all < 0.001 except BDI, = 0.001). Sleep quality was significantly poorer in the lipedema group ( < 0.001). Among PSQI subcomponents, subjective sleep quality, sleep latency, sleep duration, habitual sleep efficiency, sleep disturbances, and daytime dysfunction were significantly worse in individuals with lipedema, while sleep medication use was similar between groups ( > 0.05). In the lipedema group, PSQI scores were positively correlated with depressive (r = 0.489, = 0.006) and anxiety symptoms (r = 0.386, = 0.035). No significant associations were found between sleep quality and age, anthropometric measurements, education duration, pain severity, lipedema stage, symptom duration, or fatigue severity.ConclusionsThis study demonstrated poorer sleep quality in individuals with lipedema compared to healthy controls. Sleep quality was also associated with depressive and anxiety-related symptoms, highlighting an association between psychological symptoms and sleep problems in individuals with lipedema.
Sinonasal and Olfactory Quality of Life Following Endonasal Transsphenoidal Surgery for Pituitary Adenoma: A Multicenter Prospective Cohort Triphasic Recovery Analysis in Ethiopia
Abelti SB, Admassu AK, Wondimagegnewu EZ, Mengistu SG, Baleh AS, Woldegabriel AG, Tarekegn BA, Bedaso AG, Guduru KD and Abera PZ
Sinonasal and Olfactory Quality of Life Following Endonasal Transsphenoidal Surgery for Pituitary Adenoma: A Multicenter Prospective Cohort Triphasic Recovery Analysis in Ethiopia
Abelti SB, Admassu AK, Wondimagegnewu EZ, Mengistu SG, Baleh AS, Woldegabriel AG, Tarekegn BA, Bedaso AG, Guduru KD and Abera PZ
To characterize the sinonasal and olfactory quality of life (QoL) trajectory.
Evaluating a CBT-I Intervention in Older Adults
Sikora J, Brennan-Cook J, Downey M and Bailey DE
Evaluating a CBT-I Intervention in Older Adults
Sikora J, Brennan-Cook J, Downey M and Bailey DE
Insomnia negatively impacts quality of life and is associated with increased morbidity and mortality. Although national guidelines recommend cognitive behavioral therapy for insomnia (CBT-I), providers serving those 65 years of age and over may not have the expertise or resources to provide this treatment option. This study aimed to implement a brief online group CBT-I to adults 65 years of age and over, consisting of 4-week, 1-hour CBT-I classes at a virtual practice. The Insomnia Severity Index questionnaire was used to assess insomnia. A sleep diary was used to record an individual's quality and quantity of sleep to understand sleep patterns. A satisfaction survey was used to collect feedback on providers' experiences and perceptions during this quality improvement project. The 17 patients evaluated had a mean CBT-I score of 22.53 (standard deviation [] = 2.57) preintervention and 14.88 ( = 3.01) postintervention ([16] = 10.51, < .001). The mean difference of 7.65 (95% confidence interval [6.11, 9.18]) indicated a substantial reduction in insomnia symptoms. The effect size was large, with a Cohen's of 2.48, indicating a strong impact of the intervention on reducing insomnia symptoms. A brief cognitive behavioral intervention for patients with insomnia in a practice serving those 65 years of age and over is feasible. Additional studies are needed to determine whether this type of intervention can be used to improve patient care or patient outcomes at other practices serving older adults.Implementation of nurse-supported cognitive behavioral therapy for insomnia (CBT-I) in primary care practices serving older adults may reduce insomnia severity and improve health-related quality of life through individualized education, behavioral guidance, and ongoing support.
Corrigendum to "Management of insomnia symptoms in depressed patients treated with agomelatine, mirtazapine and trazodone: A systematic review and meta-analysis" [J. Affect. Disord. 402 (2026) 121378]
Zhang X, Chen Y, Deng R, Wang Q, Zou M and Tao S
Corrigendum to "Management of insomnia symptoms in depressed patients treated with agomelatine, mirtazapine and trazodone: A systematic review and meta-analysis" [J. Affect. Disord. 402 (2026) 121378]
Zhang X, Chen Y, Deng R, Wang Q, Zou M and Tao S
Erratum to "The development quality of generic sleep questionnaires: A systematic review and call for action" [Sleep Med Rev 90 102362]
Veirman E, De Bruecker M, Mariman A, Pevernagie DA, Hertegonne K, Bauters FA, Crombez G and Van Ryckeghem DML
Erratum to "The development quality of generic sleep questionnaires: A systematic review and call for action" [Sleep Med Rev 90 102362]
Veirman E, De Bruecker M, Mariman A, Pevernagie DA, Hertegonne K, Bauters FA, Crombez G and Van Ryckeghem DML
Anxiety and Self-Care in Adolescents with Type 1 Diabetes
Rechenberg K, Koerner R, Nguyen T and Xie R
Anxiety and Self-Care in Adolescents with Type 1 Diabetes
Rechenberg K, Koerner R, Nguyen T and Xie R
We aimed to explore the interrelationships among demographic characteristics, sleep quality, diabetes self-care behaviors, and diabetes-specific quality of life among adolescents with type 1 diabetes and anxiety symptoms.
Exploring the prevalence of risk factors for obstructive sleep apnea in women
Correa LP, Villanueva-Vilchis MDC, Ruiz-Díaz R, Fuente-Hernández J and Acosta-Torres LS
Exploring the prevalence of risk factors for obstructive sleep apnea in women
Correa LP, Villanueva-Vilchis MDC, Ruiz-Díaz R, Fuente-Hernández J and Acosta-Torres LS
Obstructive sleep apnea (OSA) is a major risk factor for several medical conditions and poor quality of life.
