Sleep abnormalities across different clinical stages of Alzheimer's disease: A systematic review and network meta-analysis
Zhang Y, Ren R, Feng X, Wang M, Huang J, Shi J, Lu L, Sanford LD, Vitiello MV and Tang X
Sleep abnormalities across different clinical stages of Alzheimer's disease: A systematic review and network meta-analysis
Zhang Y, Ren R, Feng X, Wang M, Huang J, Shi J, Lu L, Sanford LD, Vitiello MV and Tang X
Sleep disturbances play an important role in Alzheimer's disease (AD) pathology. However, it is unclear exactly how sleep changes across the AD continuum. To address this gap, we conducted a network meta-analysis to explore how sleep changes (self-reported sleep quality, daytime sleepiness, polysomnography (PSG) and actigraphy measured sleep) across the clinical stages of AD. We searched MEDLINE, EMBASE, and all EBM databases via OVID and Web of Science. Meta-analyses revealed that although sleep changes are more marked in AD dementia, there are sleep signatures in mild cognitive impairment (MCI) which may exist persistently in more advanced stage. For instance, the decreased sleep efficiency and rapid eye movement (REM) sleep percentage observed in MCI were more obvious in AD dementia, while the decreased slow wave sleep (SWS) was only observed in AD dementia but not in MCI. The increasing abnormalities in objective sleep may be considered as important indicators associated with active pathology across the AD continuum. Interventions to improve PSG measured total sleep time, SWS and REM would likely have potential for slowing AD progression, particularly if employed early in the disease process, e.g., in individuals with mild cognitive impairment due to AD or those with genetic risk for developing AD.
Impact of Barometric Pressure and Weather Conditions on Markers of Altitude Adaptation in Elite Aquatic Athletes
Mujika I, Tsai MC, Pyne DB and Stellingwerff T
Impact of Barometric Pressure and Weather Conditions on Markers of Altitude Adaptation in Elite Aquatic Athletes
Mujika I, Tsai MC, Pyne DB and Stellingwerff T
The impact of weather conditions on elite athletes' altitude adaptation is unknown.
Effects of social determinants of health in pediatric sleep-disordered breathing and allergic rhinitis management: Social determinants on SDB and AR outcomes
Reddy PD, Ocasio-Nieves B, Qian J, McMahan C, Shaffer AD, Rushchak MV and Stapleton AL
Effects of social determinants of health in pediatric sleep-disordered breathing and allergic rhinitis management: Social determinants on SDB and AR outcomes
Reddy PD, Ocasio-Nieves B, Qian J, McMahan C, Shaffer AD, Rushchak MV and Stapleton AL
To evaluate the impact of social determinants of health (SDoH) on clinical characteristics and surgical outcomes in pediatric patients with sleep-disordered breathing (SDB) and allergic rhinitis (AR) undergoing adenotonsillectomy (T&A) with or without inferior turbinate reduction (ITR).
Suboptimal 24-hour movement behavior profiles and domain-specific intrinsic capacity impairment in older adults: A community-based cross-sectional study
Huang X, Zhang Y, Zou T, Liu J, Zhang E, Lu Y, Dong A, Zhang X and Fang Q
Suboptimal 24-hour movement behavior profiles and domain-specific intrinsic capacity impairment in older adults: A community-based cross-sectional study
Huang X, Zhang Y, Zou T, Liu J, Zhang E, Lu Y, Dong A, Zhang X and Fang Q
This study aimed to identify suboptimal 24-hour movement behavior (24HMB) profiles among community-dwelling older adults and examine their associations with domain-specific intrinsic capacity (IC) impairment.
A pipeline towards missing IS-A relationship discovery in the Gene Ontology
Xiao D, Luo L, Ding P, Chen Y, Zheng C and Gao J
A pipeline towards missing IS-A relationship discovery in the Gene Ontology
Xiao D, Luo L, Ding P, Chen Y, Zheng C and Gao J
As the Gene Ontology (GO) serves as a foundational resource for biological knowledge, ensuring the completeness of its semantic structure is critically important. In this study, we introduce a novel automated pipeline to identify missing IS-A relationships in GO. The innovative core of our approach lies in employing a CNN-based model with attention, GO-FocusNet, to predict the existence of IS-A relationships between currently non-IS-A concepts. However, the large volume of non-IS-A concept pairs remains an obstacle to prediction efficiency. To address this, we retrieve concept pairs with a high likelihood of being missing IS-A relationships as candidates, by leveraging subtree structures and BoxEL-based concept embeddings. Furthermore, to minimize manual effort, we implement a two-step validation process: positive predictions are first verified using Deepseek and subsequently reviewed by domain experts. Experiments conducted on GO versions from 2022 to 2025 confirmed the effectiveness of our approach, demonstrating its value as a scalable and practical solution for ontology quality assurance.
Dupilumab for Prurigo Nodularis: Real-World Outcomes Up to 104 Weeks from the DUPItaPN Study
Talamonti M, Mortato E, Narcisi A, Ferrucci SM, Gargiulo L, Marzano AV, Napolitano M, Patruno C, Rossi M, Balato A, Gori N, Foti C, Tiberio R, Corazza M, Carugno A, Calabrese L, Pezzolo E, Esposito M, Antiga E, Trave I, Savoia P, Caroppo F, Maurelli M, Musumeci ML, Amerio P, Stingeni L, Lembo S, Satta RR, Russo F, Mariano M, Paganini C, Costanzo A, Zussino M, Del Gaudio M, Stevan E, Caccavale S, D'Amore A, Tirone B, Pertusi G, Borghi A, Lazzeri L, Magnanimi LM, Maglie R, Cozzani E, Veronese F, Belloni Fortina A, Girolomoni G, Micali G, Morea E, Hansel K, Raimondo A, Biondi G, Sordi D, Ibba L, Nicoletti M, Peris K, Sbarra G, Schettini N, Loda A, Esposto E, Cocuroccia B, Fargnoli MC, Zerbinati N, Bianchi L and Galluzzo M
Dupilumab for Prurigo Nodularis: Real-World Outcomes Up to 104 Weeks from the DUPItaPN Study
Talamonti M, Mortato E, Narcisi A, Ferrucci SM, Gargiulo L, Marzano AV, Napolitano M, Patruno C, Rossi M, Balato A, Gori N, Foti C, Tiberio R, Corazza M, Carugno A, Calabrese L, Pezzolo E, Esposito M, Antiga E, Trave I, Savoia P, Caroppo F, Maurelli M, Musumeci ML, Amerio P, Stingeni L, Lembo S, Satta RR, Russo F, Mariano M, Paganini C, Costanzo A, Zussino M, Del Gaudio M, Stevan E, Caccavale S, D'Amore A, Tirone B, Pertusi G, Borghi A, Lazzeri L, Magnanimi LM, Maglie R, Cozzani E, Veronese F, Belloni Fortina A, Girolomoni G, Micali G, Morea E, Hansel K, Raimondo A, Biondi G, Sordi D, Ibba L, Nicoletti M, Peris K, Sbarra G, Schettini N, Loda A, Esposto E, Cocuroccia B, Fargnoli MC, Zerbinati N, Bianchi L and Galluzzo M
Prurigo nodularis (PN) is a chronic, intensely pruritic skin disorder that markedly impairs quality of life. Dupilumab, an IL-4Rα antagonist, is approved for moderate-to-severe PN, but long-term real-world evidence remains limited.
Periodic limb movements in Parkinson's disease: a critical review of pathophysiology and a framework for clinical management
Yi S, Liu H, Hu X, Xu J, Zhang S, Zhang H, Wang Z, Han T, Kou L, Xia Y, Wang T, Lin Z and Xiong N
Periodic limb movements in Parkinson's disease: a critical review of pathophysiology and a framework for clinical management
Yi S, Liu H, Hu X, Xu J, Zhang S, Zhang H, Wang Z, Han T, Kou L, Xia Y, Wang T, Lin Z and Xiong N
Periodic limb movements (PLM) refer to periodic episodes of repetitive and stereotypical limb movements, predominantly affecting the lower extremities. The prevalence of PLM is estimated at 17.6% to 86.7% in patients with Parkinson's disease (PD), which is much higher than 4% to 11% in the general population. PD is a chronic neurodegenerative movement disorder characterized by both motor and non-motor symptoms (NMS), and PLM represents one of the common non-motor manifestations. PLM in PD has garnered increasing attention due to its high prevalence, association with reduced sleep quality, elevated risk of comorbidities, unclear pathophysiology, and limited treatment options. This review outlines the epidemiology and risk factors for PLM in PD patients. We explore several underlying mechanisms including iron deficiency, dopaminergic dysregulation, and sympathetic nervous activity. Treatment strategies for PLM comorbid with PD are broadly categorized into non-pharmacological and pharmacological therapies where dopamine agonists can alleviate symptoms of both PD and PLM. Clarifying the relationship between PLM and PD is essential, as it may lead to expanded novel treatment approaches and improved quality of life for affected patients.
The effect of thunder-fire moxibustion on cancer-related fatigue in patients with Qi stagnation and blood stasis type colorectal cancer undergoing chemotherapy: a randomized controlled trial
Xiaobing Y, Qidi L, Liyan L, Bin S, Yanyan H, Li B and Sixuan H
The effect of thunder-fire moxibustion on cancer-related fatigue in patients with Qi stagnation and blood stasis type colorectal cancer undergoing chemotherapy: a randomized controlled trial
Xiaobing Y, Qidi L, Liyan L, Bin S, Yanyan H, Li B and Sixuan H
This study aimed to evaluate the efficacy of thunder‑fire moxibustion (TFM) for cancer‑related fatigue (CRF) in patients with Qi stagnation and blood stasis syndrome undergoing chemotherapy for colorectal cancer.
Trait and state predictors of the intensity of emotions experienced in everyday dreams: a multilevel approach
Williams JM, Bourgin J, Varennes J, Pedreni M, Bulinski M, Blagrove M and Eichenlaub JB
Trait and state predictors of the intensity of emotions experienced in everyday dreams: a multilevel approach
Williams JM, Bourgin J, Varennes J, Pedreni M, Bulinski M, Blagrove M and Eichenlaub JB
Combination treatment for chronic insomnia disorder in adults: an American Academy of Sleep Medicine systematic review, meta-analysis, and GRADE assessment
Buysse DJ, Arnedt JT, Buenaver L, Chang JL, Fernandez-Mendoza J, Patel SI, Zhou ES, Falck-Ytter Y, Hyer S, Kazmi U, Singh M and Wickwire EM
Combination treatment for chronic insomnia disorder in adults: an American Academy of Sleep Medicine systematic review, meta-analysis, and GRADE assessment
Buysse DJ, Arnedt JT, Buenaver L, Chang JL, Fernandez-Mendoza J, Patel SI, Zhou ES, Falck-Ytter Y, Hyer S, Kazmi U, Singh M and Wickwire EM
