Circadian clock genes and insomnia: molecular mechanisms and therapeutic implications
Ren Q, Gu M and Fan X
Circadian clock genes and insomnia: molecular mechanisms and therapeutic implications
Ren Q, Gu M and Fan X
Insomnia, affecting 30-40% of the global population, is a debilitating sleep disorder linked to significant health risks, including cardiovascular disease, metabolic syndrome, and neurodegeneration. Emerging evidence implicates dysregulation of circadian clock genes as a core molecular mechanism underlying its pathophysiology.
Perivascular Dynamics, Sleep Apnoea, and Memory: Interpreting a Moving Target
Jackson ML and Rosenzweig I
Perivascular Dynamics, Sleep Apnoea, and Memory: Interpreting a Moving Target
Jackson ML and Rosenzweig I
Association between Slow-Wave Activity from Multi-Night At-Home Wireless EEG Records and Cognitive Performance in Older Adults
Qin S, Ong JL, Wong KF, Liang T, Ng EKK, Koh WP, Zhou JH and Chee MWL
Association between Slow-Wave Activity from Multi-Night At-Home Wireless EEG Records and Cognitive Performance in Older Adults
Qin S, Ong JL, Wong KF, Liang T, Ng EKK, Koh WP, Zhou JH and Chee MWL
Evidence for the association between slow wave sleep and cognitive function in older adults has been inconsistent. We measured the variability in-home EEG recordings over multiple nights to determine its impact on the association between sleep slow wave measures and cognition.
Viloxazine Extended-Release: A Review in Attention-Deficit/Hyperactivity Disorder in Adults
Syed YY
Viloxazine Extended-Release: A Review in Attention-Deficit/Hyperactivity Disorder in Adults
Syed YY
An extended-release once-daily oral capsule formulation of viloxazine (viloxazine ER; Qelbree), a norepinephrine reuptake inhibitor and serotonin receptor modulator, has been approved in the USA for the treatment of attention-deficit/hyperactivity disorder (ADHD) in paediatric patients and adults. This article reviews its use in adults with ADHD, with a brief overview of its pharmacological properties. In a randomized, double-blind, placebo-controlled, 6-week phase 3 trial, viloxazine ER significantly reduced the symptoms and severity of ADHD in adults, and improved executive function. Improvements were observed within 2-3 weeks and were sustained with continued treatment for over 24 months. Viloxazine ER was generally well tolerated in adults, with insomnia and headache being the most common adverse reactions. It has an acceptable safety profile, with no clinically significant cardiovascular or hepatic adverse effects. Current evidence supports viloxazine ER as a valuable addition to the therapeutic options available for adults with ADHD.
Does Poor Sleep Fuel Emotional Suppression? A Three-Wave RI-CLPM in Chinese Adolescents Reveals Sex-based Cultural Mechanisms
Li M, Huang J, Ma P, Dong Y, Ma Z, Zeng S, Cunningham TJ and Gong H
Does Poor Sleep Fuel Emotional Suppression? A Three-Wave RI-CLPM in Chinese Adolescents Reveals Sex-based Cultural Mechanisms
Li M, Huang J, Ma P, Dong Y, Ma Z, Zeng S, Cunningham TJ and Gong H
EEG based classification of sleep cyclic alternating patterns using frequency driven forward ternary encoding
Agarwal M and Singhal A
EEG based classification of sleep cyclic alternating patterns using frequency driven forward ternary encoding
Agarwal M and Singhal A
Cyclic alternating patterns (CAP) of sleep can be observed through electroencephalogram (EEG) signals. Analyzing CAP can provide valuable insights into different abnormalities relating to sleep. CAP comprises of two phases: A and B, characterized by the brain response to different types of stimuli.
Changes in benzodiazepine, z-drug, and other sedative prescribing in primary care in Ireland between 2014 and 2022
Mattsson M, Hassan Ali A, Boland F, Flood M, Kirke C, Wallace E, Corrigan D, Walsh ME, Fahey T and Moriarty F
Changes in benzodiazepine, z-drug, and other sedative prescribing in primary care in Ireland between 2014 and 2022
Mattsson M, Hassan Ali A, Boland F, Flood M, Kirke C, Wallace E, Corrigan D, Walsh ME, Fahey T and Moriarty F
The trends in sedative use have varied in recent years. Benzodiazepines and z-drugs are indicated for anxiety and/or sleep disorders but should be limited to short-term use. The aim of this study is to examine trends and patterns in sedative prescribing in Ireland between 2014 and 2022, as well as comparing trends between Ireland and England within the same period.
The experience and impact of living with idiopathic hypersomnia: A qualitative study of patient perspectives shared in online media
Bermingham SL, Spalding A, Bennett E and Plante DT
The experience and impact of living with idiopathic hypersomnia: A qualitative study of patient perspectives shared in online media
Bermingham SL, Spalding A, Bennett E and Plante DT
Understanding the experience and impact of idiopathic hypersomnia (IH) is critical for improving diagnosis, treatment, research, drug development, and policy awareness. Currently, physician and researcher perspectives dominate the discourse on IH, often overlooking the lived experiences of those with the condition.
Comparison of functional aspects and quality of life before and after using the heat and moisture exchange in total laryngectomy patients
Rodrigues RDS, Silva VPLD, Santos LCJD, Zica GM and Brendim MP
Comparison of functional aspects and quality of life before and after using the heat and moisture exchange in total laryngectomy patients
Rodrigues RDS, Silva VPLD, Santos LCJD, Zica GM and Brendim MP
To compare self-assessment of voice handicap, sleep quality, and quality of life related to coughing and swallowing before and after using a heat and moisture exchange filter in total laryngectomized patients.
The effect of healthy life behaviors in pregnancy on pregnant sleep quality
Karahan N, Damsarsan S, Döner Şİ and Sirkeci İ
The effect of healthy life behaviors in pregnancy on pregnant sleep quality
Karahan N, Damsarsan S, Döner Şİ and Sirkeci İ
The relationship between sleep quality in pregnancy, which is associated with adverse pregnancy outcomes, and healthy life behaviors is unclear. The aim of the study was to investigate the relationship between healthy life behaviors and sleep quality during pregnancy.
