Psychological factors beyond the SMART2 model for predicting recurrent events in atherosclerotic cardiovascular disease patients
Holtrop J, Gynnild MN, Dammen T, Dalen H, Saltvedt I, Ellekjær H, Hageman SHJ, Visseren FLJ, McEvoy JW, Dorresteijn JAN and Munkhaugen J
Psychological factors beyond the SMART2 model for predicting recurrent events in atherosclerotic cardiovascular disease patients
Holtrop J, Gynnild MN, Dammen T, Dalen H, Saltvedt I, Ellekjær H, Hageman SHJ, Visseren FLJ, McEvoy JW, Dorresteijn JAN and Munkhaugen J
Guidelines recommend using cardiovascular (CV) risk prediction models to support treatment decisions. Psychological factors such as depression, anxiety, and insomnia may affect CV risk.
Improvements in Health-Related Quality of Life in Patients with Severe Sickle Cell Disease After Exagamglogene Autotemcel
Sharma A, Locatelli F, Bhatia M, Molinari L, Mapara MY, Liem RI, Dedeken L, Wall D, Eckrich MJ, Kuo KHM, Smith W, Imren S, Kohli P, Li N, Liu T, Rubin J, Hobbs WE, Grupp SA and Frangoul H
Improvements in Health-Related Quality of Life in Patients with Severe Sickle Cell Disease After Exagamglogene Autotemcel
Sharma A, Locatelli F, Bhatia M, Molinari L, Mapara MY, Liem RI, Dedeken L, Wall D, Eckrich MJ, Kuo KHM, Smith W, Imren S, Kohli P, Li N, Liu T, Rubin J, Hobbs WE, Grupp SA and Frangoul H
Severe sickle cell disease (SCD), an inherited blood disorder characterized by recurrent vaso-occlusive crises (VOCs), has substantial negative impact on health-related quality of life (HRQoL). Exagamglogene autotemcel (exa-cel), a one-time, ex vivo CRISPR/Cas9 gene-edited cell therapy, eliminated VOCs in 97% of participants with severe SCD in the Phase 3 CLIMB SCD-121 trial. Here, we describe changes in patient-reported outcomes (PRO) measures in 30 adults and 12 adolescents who had ≥16 months follow-up in CLIMB SCD-121. Adult PRO measures included EuroQol Quality of Life Scale-5 dimensions-5 levels of severity (EQ-5D-5L), Functional Assessment of Cancer Therapy Bone Marrow Transplant (FACT-BMT), Adult Sickle Cell Quality of Life Measurement Information System (ASCQ-Me), and 11-point pain Numerical Rating Scale (NRS). In adolescents, EuroQol Quality of Life Scale-5 dimensions-youth (EQ-5D-Y), Pediatric Quality of Life Inventory (PedsQL), and pain NRS were used. Adult EQ-5D-5L health utility US and UK index and EQ VAS scores, which were lower than general population norm at baseline, substantially improved by Month 6 after exa-cel infusion and were sustained through Month 36, with similar improvements in FACT-G total and BMTS. All FACT-G (physical, social/family, emotional, functional well-being) and ASCQ-Me (emotional, social functioning, stiffness, sleep impact) subscales showed clinically meaningful improvement, including ASCQ-Me pain subscales (impact, episode frequency, severity), with substantial decreases in pain episode frequency by Month 6. Mean pain NRS score decreased by Month 6 and was sustained. Consistent with adults, adolescents had improvements in mean EQ-5D-Y VAS score, PedsQL score, and pain NRS. Exa-cel led to broad and clinically meaningful HRQoL benefits in adults and adolescents with SCD. (CLIMB SCD-121 and 131; Clinical Trials.gov numbers NCT03745287 and NCT04208529).
Using machine learning to predict concussion recovery time: The importance of psychological and symptomatic factors
Taylor E, Shurtz L, Bunt SC, Didehbani N, Cullum CM and Wilmoth K
Using machine learning to predict concussion recovery time: The importance of psychological and symptomatic factors
Taylor E, Shurtz L, Bunt SC, Didehbani N, Cullum CM and Wilmoth K
The objectives were threefold: 1) To utilize machine learning (ML) to create a model for predicting concussion recovery time using routine clinical metrics, 2) To compare predictive factors within a ML model to previously identified risk factors, and 3) To compare predictive ability of ML models to traditional logistic regression.
Development of a Theory-Based mHealth App for Fatigue Management in Lupus: Human-Centered Design Approach
Deck A, Singh K, Caras P, LeClair A, Gore-Massy M, Chiu F, Dantas LO, McAlindon T, Folta S and Kasturi S
Development of a Theory-Based mHealth App for Fatigue Management in Lupus: Human-Centered Design Approach
Deck A, Singh K, Caras P, LeClair A, Gore-Massy M, Chiu F, Dantas LO, McAlindon T, Folta S and Kasturi S
Fatigue is a highly prevalent and debilitating symptom of systemic lupus erythematosus (SLE), significantly affecting the quality of life and employment of those living with the disease. Nonpharmacologic approaches, such as physical activity interventions, have shown promise in reducing fatigue but are often resource-intensive and lack grounding in behavior change theory. Mobile health (mHealth) technology offers a scalable approach to delivering behavioral interventions.
Plasticity induced loss of apnea alarm through repeated apneas: A proposed mechanism for respiratory sudden death
Budde RB, Ganesh V, Nobis WP and Irazoqui PP
Plasticity induced loss of apnea alarm through repeated apneas: A proposed mechanism for respiratory sudden death
Budde RB, Ganesh V, Nobis WP and Irazoqui PP
We are inspired by two observations and questions. 1) In most cases of sudden unexpected death in epilepsy (SUDEP) patients experience a fatal failure to breathe which onsets a few minutes after a seizure, suggested to be of neural (not mechanical) origin. If respiration is such a critical behavior, then how could the architecture of the respiratory neural circuit ever allow an extended apnea to persist until it is fatal, especially in low-risk cases (first lifetime seizure) in which the patient's brain is not measurably impaired in any way? 2) Emerging data continue to support the theory that there are often concrete, measurable physiological changes in a patient prior to SUDEP, particularly in their respiratory reflexes and apnea drive. If this theory is true, then how could the architecture of the respiratory neural circuit acquire increased risk of fatal extended apnea? In this article we focus on the supposed "suffocation alarm" in the respiratory neural circuit, the balance of apnea and breathing, and how the balance can shift in both healthy controls and several disorders. The variations in suffocation alarm presentation suggest that the respiratory neural network can permit extended apnea without inducing alarm, arousal, or significant compensatory hyperpnea, even in healthy subjects. This apnea comfort can be induced with existing, healthy plasticity in apnea training (swimming and diving), pathologies which might mimic apnea training (repeated apneas in epilepsy, obstructive sleep apnea), or pathologies which modify the stability and feedback of the system (carotid body resection, neurodegeneration). These similarities, along with emerging data about the fundamental dynamics of the respiratory brainstem, suggest a network structure in which apnea can become a "steady state" and persist until death unless there is an outside stimulus like cardiopulmonary resuscitation.
Effects of combined auricular pressure bean and group guidance on sleep disorders in patients undergoing maintenance hemodialysis
Zheng J, Suo D, Lu H, Chen L, Liu L, Wang Y, Huang J and You T
Effects of combined auricular pressure bean and group guidance on sleep disorders in patients undergoing maintenance hemodialysis
Zheng J, Suo D, Lu H, Chen L, Liu L, Wang Y, Huang J and You T
Sleep disorders are highly prevalent and significantly impair quality of life in patients undergoing maintenance hemodialysis. This study aimed to explore the combined effect of auricular pressure bean and group guidance on sleep disorders in patients undergoing maintenance hemodialysis and its potential role in alleviating anxiety and depression.
Increased Extra-Axial Cerebrospinal Fluid Volume in Children with Angelman Syndrome: Links to Sleep Problems and Seizures
Chen Z, Garic D, Xu Y, Smith RG, Weisenfeld LAH, Kim SH, Styner MA, Piven J, Philpot BD, Hazlett HC and Shen MD
Increased Extra-Axial Cerebrospinal Fluid Volume in Children with Angelman Syndrome: Links to Sleep Problems and Seizures
Chen Z, Garic D, Xu Y, Smith RG, Weisenfeld LAH, Kim SH, Styner MA, Piven J, Philpot BD, Hazlett HC and Shen MD
Previous studies demonstrated that children with autism have enlarged volumes of extra-axial cerebrospinal fluid (EA-CSF) and increased ratio of EA-CSF to brain volume, indicating that EA-CSF is disproportionally increased beyond macrocephaly often observed in autism. It is unknown whether EA-CSF is disproportionally enlarged in Angelman syndrome (AS), which shares phenotypic features with autism (sleep problems, seizures) but is characterized by microcephaly. This study examined EA-CSF and total cerebral volume (TCV) in AS children compared to neurotypical (NT) controls to test whether EA-CSF is disproportionally enlarged and is associated with sleep problems and seizures.
Implementation of Stimulus Control and Sleep Restriction Therapy for Insomnia: Standard Definitions and Best Practices
Cuddihy LJ, Grandner MA and Nowakowski S
Implementation of Stimulus Control and Sleep Restriction Therapy for Insomnia: Standard Definitions and Best Practices
Cuddihy LJ, Grandner MA and Nowakowski S
Physical and mental health well-being of COVID-19 recovered patients: A phenomenological study
Abuhammad S, Alzoubi KH, Khabour OF, Hamaideh S, Khasawneh B and El-Zubi M
Physical and mental health well-being of COVID-19 recovered patients: A phenomenological study
Abuhammad S, Alzoubi KH, Khabour OF, Hamaideh S, Khasawneh B and El-Zubi M
This study aims to describe the experience of COVID-19 recovered patients' physical and mental health well-being.
Development of the MSKP index: Risk model of musculoskeletal pain in Colombian adolescents
Alfonso-Mora ML, Sánchez-Vera MA, Uribe-Laverde MA, García Becerra AM and Gonzalez PS
Development of the MSKP index: Risk model of musculoskeletal pain in Colombian adolescents
Alfonso-Mora ML, Sánchez-Vera MA, Uribe-Laverde MA, García Becerra AM and Gonzalez PS
This study aimed to develop a model to evaluate the risk of musculoskeletal pain (MSKP) in adolescents and identify the associated factors.
