Sleep doctors Ft. Myers, Bonita Springs, Cape Coral, Lehigh, Estero | Somnas Sleep Apnea, Insomnia, Sleep Disorder

Sleep and Intensive Care Unit-Acquired Weakness in Critically Ill Older Adults.

Sleep and Intensive Care Unit-Acquired Weakness in Critically Ill Older Adults.
Dimens Crit Care Nurs. 2019 Jan/Feb;38(1):20-28
Authors: Elías MN, Munro CL, Liang Z, Calero K, Ji M
BACKGROUND: Older adults in the intensive care unit (ICU) often experience sleep disturbances, which may stem from life-threatening illness, the ICU environment, medications/sedation, or psychological stress. Two complementary endocrinological responses occur as a result of compromised sleep and consequently could exacerbate ICU-acquired weakness: a decrease in anabolic hormones leading to decreased protein synthesis and an increase in catabolic hormones leading to increased protein degradation. Age-associated decreases in anabolic hormones, such as insulin-like growth factor 1, testosterone, and growth hormone, may inhibit protein synthesis. Likewise, age-associated increases in insulin resistance, glucocorticoids, and myostatin can stimulate muscle atrophy and further reduce protein synthesis. Thus, perhaps, sleep promotion in the ICU may attenuate muscle atrophy among critically ill older adults who are at risk for ICU-acquired weakness and subsequent functional decline.
OBJECTIVES: The aim of this study was to discuss the hypothesized theoretical underpinnings of the relationship between sleep disturbances and ICU-acquired weakness among critically ill older adults.
METHODS: A search of research literature published from 1970 to 2018 and indexed in MEDLINE, Embase, CINAHL, and Ovid was undertaken, and relevant sources were selected to build an informed discussion.
RESULTS: Nurses must be mindful of secondary sleep disturbances that occur throughout the acute phase of critical illness and their probable links to ICU-acquired weakness. Targeted interventions to promote functional outcomes in elderly patients should consider this relationship.
DISCUSSION: Improved sleep may have the potential to decrease the severity of muscle atrophy and ICU-acquired weakness. Future research must explore this hypothesis and the underlying mechanisms of the association between sleep disturbances and ICU-acquired weakness in critically ill older adults.PMID: 30499789 [PubMed – in process]

Leave a Comment

Your email address will not be published. Required fields are marked *

Scroll to Top
Sleep well, live well

Starting on October 11, 2023, Allergy Sleep & Lung Care (ASLC) will no longer be affiliated with GenesisCare due to their bankruptcy.

ASLC will be reopening as an independent practice at our Healthpark office on or after October 30, 2023.

Please don’t hesitate to reach out to us through any of the following contact channels:

Phone/text: 239-932-3023 / 239-437-6670


A partir del 11 de octubre de 2023, Allergy Sleep & Lung Care (ASLC) ya no formará parte de GenesisCare debido a su quiebra.

ASLC volverá a abrir como una práctica independiente en nuestra oficina de Healthpark a partir del 30 de octubre de 2023 o después de esa fecha.

No dudes en ponerte en contacto con nosotros a través de cualquiera de los siguientes canales:

Teléfono/mensaje de texto: 239-932-3023 / 239-437-6670

Correo electrónico: 

This website stores cookies on your computer so that we can give you the best experience on our website. If you continue to use this site we will assume that you are happy with it.


Somnas offers state-of-the-art diagnostic options to identify specific sleep disorders and manage them using the latest treatments and therapies with an individualized treatment plan to ensure long-term optimal outcomes.